{"id":748,"date":"2026-08-21T20:54:00","date_gmt":"2026-08-21T11:54:00","guid":{"rendered":"https:\/\/maekawa.clinic\/column\/?p=748"},"modified":"2026-10-14T13:29:33","modified_gmt":"2026-10-14T04:29:33","slug":"exosome-nasal-safety-side-effects","status":"publish","type":"post","link":"https:\/\/maekawa.clinic\/column\/exosome\/exosome-nasal-safety-side-effects\/","title":{"rendered":"\u30a8\u30af\u30bd\u30bd\u30fc\u30e0\u70b9\u9f3b\u306f\u5371\u967a\uff1f\u6b7b\u4ea1\u4e8b\u4f8b\u30fb\u526f\u4f5c\u7528\u30fb\u5b89\u5168\u6027\u3068\u6cbb\u7642\u524d\u306e\u6ce8\u610f\u70b9\u3092\u89e3\u8aac"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\">\u30a8\u30af\u30bd\u30bd\u30fc\u30e0\u70b9\u9f3b\u306b\u8208\u5473\u306f\u3042\u308b\u3082\u306e\u306e\u3001<mark style=\"background-color:rgba(0, 0, 0, 0);color:#cc3939\" 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font-size: 24px;\n    color: #5b4b4b;\n}\n\n.reference-note {\n    color: #777;\n    font-size: 12px;\n    line-height: 1.8;\nmargin-bottom: 0!important;\n}\n\n.reference-list {\n    list-style: none!important;\n    padding: 0;\n    margin: 0!important;\n}\n\n.reference-list li {\n    padding: 20px 0;\n    border-bottom: 1px solid #f1e5ea;\n}\n\n.reference-list li:last-child {\n    border-bottom: none;\n}\n\n.reference-list a {\n    display: block;\n    margin-bottom: 6px;\n    color: #c75c7c;\n    font-size: 17px;\n    font-weight: 600;\n    text-decoration: none;\n    transition: 0.2s;\n}\n\n.reference-list a:hover {\n    color: #a94462;\n    text-decoration: underline;\n}\n\n.reference-list span {\n    display: block;\n    color: #666;\n    font-size: 14px;\n    line-height: 1.7;\n}\n<\/style>\n\n<section class=\"reference-box\">\n  <div class=\"reference-title\">\u53c2\u8003\u6587\u732e\u30fb\u53c2\u8003\u30ea\u30f3\u30af<\/div>\n  <p class=\"reference-note\">\n    \u4e0b\u8a18\u306e\u60c5\u5831\u3092\u53c2\u8003\u306b\u8a18\u8ff0\u3057\u3066\u3044\u307e\u3059\u3002\n  <\/p>\n\n  <ul class=\"reference-list\">\n    <li>\n      <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/37859748\/\" target=\"_blank\" rel=\"noopener noreferrer\">\n        PubMed\uff08PMID: 37859748\uff09\n      <\/a>\n      <span>Xie X, Song Q, Dai C, Cui S, Tang R, Li S, Chang J, Li P, Wang J, Li J, Gao C, Chen H, Chen S, Ren R, Gao X, Wang G. Clinical safety and efficacy of allogenic human adipose mesenchymal stromal cells-derived exosomes in patients with mild to moderate Alzheimer&#8217;s disease: a phase I\/II clinical trial. Gen Psychiatr. 2023 Oct 11<\/span>\n    <\/li>\n  <\/ul>\n<\/section>\n\n\n\n<p class=\"wp-block-paragraph\">\u4e00\u65b9\u3067\u3053\u308c\u3089\u306e\u7814\u7a76\u3060\u3051\u3092\u3082\u3063\u3066\u3001\u4e00\u822c\u7684\u306a\u627f\u8a8d\u533b\u85ac\u54c1\u3068\u540c\u3058\u3088\u3046\u306b\u6709\u52b9\u6027\u3084\u9577\u671f\u7684\u306a\u5b89\u5168\u6027\u304c\u5341\u5206\u78ba\u7acb\u3055\u308c\u3066\u3044\u308b\u308f\u3051\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002<\/p>\n\n\n\n<p 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background: #fffafc;\n    border: 1px solid #f4d9e2;\n    border-radius: 20px;\nline-height: 1.3;\n}\n\n.reference-title {\n    font-size: 24px;\n    color: #5b4b4b;\n}\n\n.reference-note {\n    color: #777;\n    font-size: 12px;\n    line-height: 1.8;\nmargin-bottom: 0!important;\n}\n\n.reference-list {\n    list-style: none!important;\n    padding: 0;\n    margin: 0!important;\n}\n\n.reference-list li {\n    padding: 20px 0;\n    border-bottom: 1px solid #f1e5ea;\n}\n\n.reference-list li:last-child {\n    border-bottom: none;\n}\n\n.reference-list a {\n    display: block;\n    margin-bottom: 6px;\n    color: #c75c7c;\n    font-size: 17px;\n    font-weight: 600;\n    text-decoration: none;\n    transition: 0.2s;\n}\n\n.reference-list a:hover {\n    color: #a94462;\n    text-decoration: underline;\n}\n\n.reference-list span {\n    display: block;\n    color: #666;\n    font-size: 14px;\n    line-height: 1.7;\n}\n<\/style>\n\n<section class=\"reference-box\">\n  <div class=\"reference-title\">\u53c2\u8003\u6587\u732e\u30fb\u53c2\u8003\u30ea\u30f3\u30af<\/div>\n  <p class=\"reference-note\">\n    \u4e0b\u8a18\u306e\u60c5\u5831\u3092\u53c2\u8003\u306b\u8a18\u8ff0\u3057\u3066\u3044\u307e\u3059\u3002\n  <\/p>\n\n  <ul class=\"reference-list\">\n    <li>\n      <a href=\"https:\/\/www.mhlw.go.jp\/content\/001281987.pdf\" target=\"_blank\" rel=\"noopener noreferrer\">\n        \u5e79\u7d30\u80de\u57f9\u990a\u4e0a\u6e05\u6db2\u53ca\u3073\u30a8\u30af\u30bd\u30bd\u30fc\u30e0\u7b49\u3092\u7528\u3044\u308b\u533b\u7642\u306b\u3064\u3044\u3066\uff08\u5468\u77e5\uff09\n      <\/a>\n      <span>\u539a\u751f\u52b4\u50cd\u7701<\/span>\n    <\/li>\n    <li>\n      <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/38738585\/\" target=\"_blank\" rel=\"noopener noreferrer\">\n        PubMed\uff08PMID: 38738585\uff09\n      <\/a>\n      <span>Fusco C, De Rosa G, Spatocco I, Vitiello E, Procaccini C, Frig\u00e8 C, Pellegrini V, La Grotta R, Furlan R, Matarese G, Prattichizzo F, de Candia P. Extracellular vesicles as human therapeutics: A scoping review of the literature. J Extracell Vesicles. 2024 May;13(5)<\/span>\n    <\/li>\n    <li>\n      <a href=\"https:\/\/www.jsrm.jp\/news\/news-15720\/\" target=\"_blank\" rel=\"noopener noreferrer\">\n        iPS\u7d30\u80de\u7531\u6765\u30a8\u30af\u30bd\u30bd\u30fc\u30e0\u306e\u81e8\u5e8a\u5fdc\u7528\u306b\u3064\u3044\u3066\uff08\u6ce8\u610f\u559a\u8d77\uff09\n      <\/a>\n      <span>\u4e00\u822c\u793e\u56e3\u6cd5\u4eba \u65e5\u672c\u518d\u751f\u533b\u7642\u5b66\u4f1a<\/span>\n    <\/li>\n  <\/ul>\n<\/section>\n\n\n\n<h2 id=\"aioseo-\u30a8\u30af\u30bd\u30bd\u30fc\u30e0\u70b9\u9f3b\u304c\u5371\u967a\u3068\u3044\u308f\u308c\u308b\u7406\u7531-24\" class=\"wp-block-heading\">\u30a8\u30af\u30bd\u30bd\u30fc\u30e0\u70b9\u9f3b\u304c\u5371\u967a\u3068\u3044\u308f\u308c\u308b\u7406\u7531<\/h2>\n\n\n\n<h3 id=\"aioseo-\u65b0\u3057\u3044\u6cbb\u7642\u65b9\u6cd5\u3067\u3042\u308a\u7814\u7a76\u6bb5\u968e\u306e\u5206\u91ce-25\" class=\"wp-block-heading\">\u65b0\u3057\u3044\u6cbb\u7642\u65b9\u6cd5\u3067\u3042\u308a\u3001\u7814\u7a76\u6bb5\u968e\u306e\u5206\u91ce<\/h3>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"1024\" src=\"https:\/\/maekawa.clinic\/column\/wp-content\/uploads\/2026\/08\/\u30a8\u30af\u30bd\u30bd\u30fc\u30e0\u70b9\u9f3b\u306e\u7814\u7a76\u6bb5\u968e\u30ac\u30a4\u30c9-1024x1024.jpg\" 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#f1e5ea;\n}\n\n.reference-list li:last-child {\n    border-bottom: none;\n}\n\n.reference-list a {\n    display: block;\n    margin-bottom: 6px;\n    color: #c75c7c;\n    font-size: 17px;\n    font-weight: 600;\n    text-decoration: none;\n    transition: 0.2s;\n}\n\n.reference-list a:hover {\n    color: #a94462;\n    text-decoration: underline;\n}\n\n.reference-list span {\n    display: block;\n    color: #666;\n    font-size: 14px;\n    line-height: 1.7;\n}\n<\/style>\n\n<section class=\"reference-box\">\n  <div class=\"reference-title\">\u53c2\u8003\u6587\u732e\u30fb\u53c2\u8003\u30ea\u30f3\u30af<\/div>\n  <p class=\"reference-note\">\n    \u4e0b\u8a18\u306e\u60c5\u5831\u3092\u53c2\u8003\u306b\u8a18\u8ff0\u3057\u3066\u3044\u307e\u3059\u3002\n  <\/p>\n\n  <ul class=\"reference-list\">\n    <li>\n      <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/38311623\/\" target=\"_blank\" rel=\"noopener noreferrer\">\n        PubMed\uff08PMID: 38311623\uff09\n      <\/a>\n      <span>Kumar MA, Baba SK, Sadida HQ, Marzooqi SA, Jerobin J, Altemani FH, Algehainy N, Alanazi MA, Abou-Samra AB, Kumar R, Al-Shabeeb Akil AS, Macha MA, Mir R, Bhat AA. Extracellular vesicles as tools and targets in therapy for diseases. Signal Transduct Target Ther. 2024 Feb 5<\/span>\n    <\/li>\n  <\/ul>\n<\/section>\n\n\n\n<h3 id=\"aioseo-\u65e5\u672c\u3067\u306f\u627f\u8a8d\u533b\u85ac\u54c1\u3068\u3057\u3066\u4f7f\u7528\u3055\u308c\u3066\u3044\u308b\u308f\u3051\u3067\u306f\u306a\u3044-33\" class=\"wp-block-heading\">\u65e5\u672c\u3067\u306f\u627f\u8a8d\u533b\u85ac\u54c1\u3068\u3057\u3066\u4f7f\u7528\u3055\u308c\u3066\u3044\u308b\u308f\u3051\u3067\u306f\u306a\u3044<\/h3>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"1024\" src=\"https:\/\/maekawa.clinic\/column\/wp-content\/uploads\/2026\/08\/\u65e5\u672c\u306e\u672a\u627f\u8a8d\u533b\u85ac\u54c1\u306b\u95a2\u3059\u308b\u6ce8\u610f\u559a\u8d77-1024x1024.jpg\" 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https:\/\/maekawa.clinic\/column\/wp-content\/uploads\/2026\/08\/\u88fd\u5264\u54c1\u8cea\u306e\u9055\u3044\u3092\u77e5\u308b-infographic-150x150.jpg 150w, https:\/\/maekawa.clinic\/column\/wp-content\/uploads\/2026\/08\/\u88fd\u5264\u54c1\u8cea\u306e\u9055\u3044\u3092\u77e5\u308b-infographic-768x768.jpg 768w, https:\/\/maekawa.clinic\/column\/wp-content\/uploads\/2026\/08\/\u88fd\u5264\u54c1\u8cea\u306e\u9055\u3044\u3092\u77e5\u308b-infographic-214x214.jpg 214w, https:\/\/maekawa.clinic\/column\/wp-content\/uploads\/2026\/08\/\u88fd\u5264\u54c1\u8cea\u306e\u9055\u3044\u3092\u77e5\u308b-infographic-158x158.jpg 158w, https:\/\/maekawa.clinic\/column\/wp-content\/uploads\/2026\/08\/\u88fd\u5264\u54c1\u8cea\u306e\u9055\u3044\u3092\u77e5\u308b-infographic.jpg 1254w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p 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1.3;\n}\n\n.reference-title {\n    font-size: 24px;\n    color: #5b4b4b;\n}\n\n.reference-note {\n    color: #777;\n    font-size: 12px;\n    line-height: 1.8;\nmargin-bottom: 0!important;\n}\n\n.reference-list {\n    list-style: none!important;\n    padding: 0;\n    margin: 0!important;\n}\n\n.reference-list li {\n    padding: 20px 0;\n    border-bottom: 1px solid #f1e5ea;\n}\n\n.reference-list li:last-child {\n    border-bottom: none;\n}\n\n.reference-list a {\n    display: block;\n    margin-bottom: 6px;\n    color: #c75c7c;\n    font-size: 17px;\n    font-weight: 600;\n    text-decoration: none;\n    transition: 0.2s;\n}\n\n.reference-list a:hover {\n    color: #a94462;\n    text-decoration: underline;\n}\n\n.reference-list span {\n    display: block;\n    color: #666;\n    font-size: 14px;\n    line-height: 1.7;\n}\n<\/style>\n\n<section class=\"reference-box\">\n  <div class=\"reference-title\">\u53c2\u8003\u6587\u732e\u30fb\u53c2\u8003\u30ea\u30f3\u30af<\/div>\n  <p class=\"reference-note\">\n    \u4e0b\u8a18\u306e\u60c5\u5831\u3092\u53c2\u8003\u306b\u8a18\u8ff0\u3057\u3066\u3044\u307e\u3059\u3002\n  <\/p>\n\n  <ul class=\"reference-list\">\n    <li>\n      <a href=\"https:\/\/www.jsrm.jp\/cms\/uploads\/2024\/05\/news14993-2.pdf\" target=\"_blank\" rel=\"noopener noreferrer\">\n\u7d30\u80de\u5916\u5c0f\u80de\u7b49\u306e\u81e8\u5e8a\u5fdc\u7528\u306b\u95a2\u3059\u308b\u30ac\u30a4\u30c0\u30f3\u30b9\uff08\u7b2c\uff11\u7248\uff09\n      <\/a>\n      <span>\u4e00\u822c\u793e\u56e3\u6cd5\u4eba \u65e5\u672c\u518d\u751f\u533b\u7642\u5b66\u4f1a<\/span>\n    <\/li>\n    <li>\n      <a href=\"https:\/\/www.jsrm.jp\/news\/news-18183\/\" target=\"_blank\" rel=\"noopener noreferrer\">\n\u3010PMDA\u3011\u3000\u300c\u521d\u56de\u6cbb\u9a13\u5c4a\u6642\u306b\u7559\u610f\u3059\u3079\u304d\u30d2\u30c8\u7d30\u80de\u7531\u6765\u306e\u7d30\u80de\u5916\u5c0f\u80de\uff08Extracellular Vesicles\uff1bEV\uff09\u88fd\u5264\u306e\u54c1\u8cea\u95a2\u9023\u4e8b\u9805\u306b\u3064\u3044\u3066\uff08Early Consideration\uff09\u300d\n      <\/a>\n      <span>\u4e00\u822c\u793e\u56e3\u6cd5\u4eba \u65e5\u672c\u518d\u751f\u533b\u7642\u5b66\u4f1a<\/span>\n    <\/li>\n  <\/ul>\n<\/section>\n\n\n\n<h2 id=\"aioseo-\u904e\u53bb\u306b\u306f\u6b7b\u4ea1\u4e8b\u4f8b\u3082\u3042\u308b\u30a8\u30af\u30bd\u30bd\u30fc\u30e0\u70b9\u9f3b\u3068\u306e\u9055\u3044-53\" class=\"wp-block-heading\">\u904e\u53bb\u306b\u306f\u6b7b\u4ea1\u4e8b\u4f8b\u3082\u3042\u308b\uff1f\u30a8\u30af\u30bd\u30bd\u30fc\u30e0\u70b9\u9f3b\u3068\u306e\u9055\u3044<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u30a8\u30af\u30bd\u30bd\u30fc\u30e0\u306b\u3064\u3044\u3066\u8abf\u3079\u308b\u3068\u3001\u904e\u53bb\u306b\u6b7b\u4ea1\u4e8b\u4f8b\u3084\u5065\u5eb7\u88ab\u5bb3\u306b\u95a2\u3059\u308b\u60c5\u5831\u3092\u76ee\u306b\u3059\u308b\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u4e0d\u5b89\u306b\u306a\u308b\u60c5\u5831\u3067\u3059\u304c\u3001\u3053\u308c\u3089\u306f\u6295\u4e0e\u3057\u305f\u88fd\u5264\u3084\u6cbb\u7642\u65b9\u6cd5\u304c\u7570\u306a\u308b\u305f\u3081\u3001\u904e\u53bb\u306b\u516c\u8868\u3055\u308c\u305f\u4e8b\u4f8b\u3092\u78ba\u8a8d\u3057\u306a\u304c\u3089\u3001\u30a8\u30af\u30bd\u30bd\u30fc\u30e0\u70b9\u9f3b\u3068\u306e\u9055\u3044\u3092\u6574\u7406\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<h3 id=\"aioseo-2023\u5e74\u5e79\u7d30\u80de\u57f9\u990a\u4e0a\u6e05\u6db2\u3092\u4f7f\u7528\u3057\u305f\u6cbb\u7642\u3067\u6b7b\u4ea1\u60c5\u5831-56\" class=\"wp-block-heading\">2023\u5e74\uff5c\u5e79\u7d30\u80de\u57f9\u990a\u4e0a\u6e05\u6db2\u3092\u4f7f\u7528\u3057\u305f\u6cbb\u7642\u3067\u6b7b\u4ea1\u60c5\u5831<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">2023\u5e7410\u6708\u3001\u518d\u751f\u533b\u7642\u6297\u52a0\u9f62\u5b66\u4f1a\u306f\u300c\u5e79\u7d30\u80de\u57f9\u990a\u4e0a\u6e05\u6db2\u3092\u4f7f\u7528\u3057\u305f\u6cbb\u7642\u306b\u95a2\u3057\u3001\u60a3\u8005\u304c\u6b7b\u4ea1\u3059\u308b\u3068\u3044\u3046\u4e8b\u8c61\u304c\u767a\u751f\u3057\u305f\u3068\u306e\u60c5\u5831\u306b\u63a5\u3057\u3066\u3044\u308b\u300d\u3068\u516c\u8868\u3057\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u540c\u5b66\u4f1a\u306f\u3053\u308c\u3092\u53d7\u3051\u3001\u5e79\u7d30\u80de\u57f9\u990a\u4e0a\u6e05\u6db2\u304a\u3088\u3073\u30a8\u30af\u30bd\u30bd\u30fc\u30e0\u306e<strong>\u9759\u8108\u6295\u4e0e<\/strong>\u306b\u3064\u3044\u3066\u3001\u533b\u7642\u6c34\u6e96\u3068\u3057\u3066\u672a\u78ba\u7acb\u306e\u7642\u6cd5\u3067\u3042\u308b\u3068\u3057\u3066\u3001\u6709\u52b9\u6027\u30fb\u5b89\u5168\u6027\u306b\u3064\u3044\u3066\u30a8\u30d3\u30c7\u30f3\u30b9\u306b\u57fa\u3065\u304f\u5341\u5206\u306a\u691c\u8a0e\u3092\u6c42\u3081\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u307e\u305f\u3001\u3053\u306e\u516c\u8868\u8cc7\u6599\u304b\u3089\u30a8\u30af\u30bd\u30bd\u30fc\u30e0\u306e\u6295\u4e0e\u305d\u306e\u3082\u306e\u304c\u6b7b\u4ea1\u539f\u56e0\u3060\u3063\u305f\u3068\u5224\u65ad\u3067\u304d\u308b\u8a18\u8f09\u304c\u3042\u308b\u308f\u3051\u3067\u306f\u306a\u3044\u3068\u3044\u3046\u70b9\u3068\u3001\u3053\u3053\u3067\u5831\u544a\u3055\u308c\u3066\u3044\u308b\u306e\u306f\u300c\u5e79\u7d30\u80de\u57f9\u990a\u4e0a\u6e05\u6db2\u3092\u4f7f\u7528\u3057\u305f\u6cbb\u7642\u300d\u306b\u95a2\u3059\u308b\u6b7b\u4ea1\u60c5\u5831\u3067\u3042\u308a\u3001<strong>\u30a8\u30af\u30bd\u30bd\u30fc\u30e0\u70b9\u9f3b\u306b\u3088\u308b\u6b7b\u4ea1\u4e8b\u4f8b\u3068\u3057\u3066\u5831\u544a\u3055\u308c\u305f\u3082\u306e\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u30a8\u30af\u30bd\u30bd\u30fc\u30e0\u70b9\u9f3b\u306e\u5371\u967a\u6027\u3092\u8003\u3048\u308b\u969b\u306b\u306f\u3001\u6295\u4e0e\u3059\u308b\u88fd\u5264\u306e\u7a2e\u985e\u3084\u6295\u4e0e\u7d4c\u8def\u3092\u533a\u5225\u3057\u3066\u60c5\u5831\u3092\u78ba\u8a8d\u3059\u308b\u3053\u3068\u304c\u91cd\u8981\u3067\u3059\u3002<\/p>\n\n\n\n<style data-wp-block-html=\"css\">\n.reference-box {\n    margin: 40px 0;\n    padding: 5% 5% 0 5%;\n    background: #fffafc;\n    border: 1px solid #f4d9e2;\n    border-radius: 20px;\nline-height: 1.3;\n}\n\n.reference-title {\n    font-size: 24px;\n    color: #5b4b4b;\n}\n\n.reference-note {\n    color: #777;\n    font-size: 12px;\n    line-height: 1.8;\nmargin-bottom: 0!important;\n}\n\n.reference-list {\n    list-style: none!important;\n    padding: 0;\n    margin: 0!important;\n}\n\n.reference-list li {\n    padding: 20px 0;\n    border-bottom: 1px solid #f1e5ea;\n}\n\n.reference-list li:last-child {\n    border-bottom: none;\n}\n\n.reference-list a {\n    display: block;\n    margin-bottom: 6px;\n    color: #c75c7c;\n    font-size: 17px;\n    font-weight: 600;\n    text-decoration: none;\n    transition: 0.2s;\n}\n\n.reference-list a:hover {\n    color: #a94462;\n    text-decoration: underline;\n}\n\n.reference-list span {\n    display: block;\n    color: #666;\n    font-size: 14px;\n    line-height: 1.7;\n}\n<\/style>\n\n<section class=\"reference-box\">\n  <div class=\"reference-title\">\u53c2\u8003\u6587\u732e\u30fb\u53c2\u8003\u30ea\u30f3\u30af<\/div>\n  <p class=\"reference-note\">\n    \u4e0b\u8a18\u306e\u60c5\u5831\u3092\u53c2\u8003\u306b\u8a18\u8ff0\u3057\u3066\u3044\u307e\u3059\u3002\n  <\/p>\n\n  <ul class=\"reference-list\">\n    <li>\n      <a href=\"https:\/\/aarm.jp\/news\/%E5%B9%B9%E7%B4%B0%E8%83%9E%E4%B8%8A%E6%B8%85%E6%B6%B2%E3%81%AB%E9%96%A2%E3%81%99%E3%82%8B%E6%AD%BB%E4%BA%A1%E4%BA%8B%E4%BE%8B%E3%81%AE%E7%99%BA%E7%94%9F%E3%81%AB%E3%81%A4%E3%81%84%E3%81%A6\/\" target=\"_blank\" rel=\"noopener noreferrer\">\n       \u5e79\u7d30\u80de\u57f9\u990a\u4e0a\u6e05\u6db2\u306b\u95a2\u3059\u308b\u6b7b\u4ea1\u4e8b\u4f8b\u306e\u767a\u751f\u306b\u3064\u3044\u3066\n      <\/a>\n      <span>\u4e00\u822c\u793e\u56e3\u6cd5\u4eba\u518d\u751f\u533b\u7642\u6297\u52a0\u9f62\u5b66\u4f1a<\/span>\n    <\/li>\n  <\/ul>\n<\/section>\n\n\n\n<h3 id=\"aioseo-2025\u5e74\u81ea\u5df1\u8102\u80aa\u7531\u6765\u9593\u8449\u7cfb\u5e79\u7d30\u80de\u306e\u6295\u4e0e\u4e2d\u306b\u6b7b\u4ea1-62\" class=\"wp-block-heading\">2025\u5e74\uff5c\u81ea\u5df1\u8102\u80aa\u7531\u6765\u9593\u8449\u7cfb\u5e79\u7d30\u80de\u306e\u6295\u4e0e\u4e2d\u306b\u6b7b\u4ea1<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">2025\u5e748\u6708\u3001\u539a\u751f\u52b4\u50cd\u7701\u306f\u3001\u6162\u6027\u75bc\u75db\u306b\u5bfe\u3059\u308b\u300c\u81ea\u5df1\u8102\u80aa\u7531\u6765\u9593\u8449\u7cfb\u5e79\u7d30\u80de\u300d\u306b\u3088\u308b\u6cbb\u7642\u3092\u53d7\u3051\u305f\u60a3\u80051\u540d\u304c\u3001\u6295\u4e0e\u4e2d\u306b\u6025\u5909\u3057\u3001\u6025\u901f\u306b\u5fc3\u505c\u6b62\u306b\u81f3\u308a\u6b7b\u4ea1\u78ba\u8a8d\u3055\u308c\u305f\u3053\u3068\u304c\u8a18\u8f09\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u539a\u52b4\u7701\u306f\u305d\u306e\u4e8b\u6848\u3092\u53d7\u3051\u3001\u518d\u751f\u533b\u7642\u306e\u63d0\u4f9b\u3068\u7279\u5b9a\u7d30\u80de\u52a0\u5de5\u7269\u7b49\u306e\u88fd\u9020\u306b\u3064\u3044\u3066\u4e00\u6642\u505c\u6b62\u306e\u7dca\u6025\u547d\u4ee4\u3092\u51fa\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3055\u3089\u306b\u30012026\u5e741\u670823\u65e5\u306b\u306f\u3001\u95a2\u9023\u3059\u308b\u7d30\u80de\u52a0\u5de5\u65bd\u8a2d\u306b\u5bfe\u3057\u3066\u6539\u5584\u547d\u4ee4\u304c\u51fa\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<style data-wp-block-html=\"css\">\n.reference-box {\n    margin: 40px 0;\n    padding: 5% 5% 0 5%;\n    background: #fffafc;\n    border: 1px solid #f4d9e2;\n    border-radius: 20px;\nline-height: 1.3;\n}\n\n.reference-title {\n    font-size: 24px;\n    color: #5b4b4b;\n}\n\n.reference-note {\n    color: #777;\n    font-size: 12px;\n    line-height: 1.8;\nmargin-bottom: 0!important;\n}\n\n.reference-list {\n    list-style: none!important;\n    padding: 0;\n    margin: 0!important;\n}\n\n.reference-list li {\n    padding: 20px 0;\n    border-bottom: 1px solid #f1e5ea;\n}\n\n.reference-list li:last-child {\n    border-bottom: none;\n}\n\n.reference-list a {\n    display: block;\n    margin-bottom: 6px;\n    color: #c75c7c;\n    font-size: 17px;\n    font-weight: 600;\n    text-decoration: none;\n    transition: 0.2s;\n}\n\n.reference-list a:hover {\n    color: #a94462;\n    text-decoration: underline;\n}\n\n.reference-list span {\n    display: block;\n    color: #666;\n    font-size: 14px;\n    line-height: 1.7;\n}\n<\/style>\n\n<section class=\"reference-box\">\n  <div class=\"reference-title\">\u53c2\u8003\u6587\u732e\u30fb\u53c2\u8003\u30ea\u30f3\u30af<\/div>\n  <p class=\"reference-note\">\n    \u4e0b\u8a18\u306e\u60c5\u5831\u3092\u53c2\u8003\u306b\u8a18\u8ff0\u3057\u3066\u3044\u307e\u3059\u3002\n  <\/p>\n\n  <ul class=\"reference-list\">\n    <li>\n      <a href=\"https:\/\/www.mhlw.go.jp\/stf\/newpage_62642.html\" target=\"_blank\" rel=\"noopener noreferrer\">\n       \u518d\u751f\u533b\u7642\u7b49\u306e\u5b89\u5168\u6027\u306e\u78ba\u4fdd\u7b49\u306b\u95a2\u3059\u308b\u6cd5\u5f8b\u306b\u57fa\u3065\u304f\u7dca\u6025\u547d\u4ee4\u306b\u3064\u3044\u3066\n      <\/a>\n      <span>\u539a\u751f\u52b4\u50cd\u7701<\/span>\n    <\/li>\n  <\/ul>\n<\/section>\n\n\n\n<h3 id=\"aioseo-2026\u5e74\u5225\u306e\u5e79\u7d30\u80de\u6cbb\u7642\u3067\u3082\u6b7b\u4ea1\u4e8b\u4f8b-67\" class=\"wp-block-heading\">2026\u5e74\uff5c\u5225\u306e\u5e79\u7d30\u80de\u6cbb\u7642\u3067\u3082\u6b7b\u4ea1\u4e8b\u4f8b<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">2026\u5e743\u670813\u65e5\u306e\u539a\u52b4\u7701\u8cc7\u6599\u3067\u306f\u3001\u533b\u7642\u6a5f\u95a2\u3067\u81ea\u5bb6\u8102\u80aa\u7531\u6765\u9593\u8449\u7cfb\u5e79\u7d30\u80de\u3092\u7528\u3044\u305f\u6162\u6027\u75bc\u75db\u6cbb\u7642\u3092\u53d7\u3051\u305f\u60a3\u80051\u540d\u304c\u3001\u6295\u4e0e\u4e2d\u306b\u6025\u5909\u3057\u3001\u6025\u901f\u306b\u5fc3\u505c\u6b62\u306b\u81f3\u308a\u6b7b\u4ea1\u78ba\u8a8d\u3055\u308c\u305f\u3068\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u539f\u56e0\u304c\u660e\u3089\u304b\u306b\u306a\u3063\u3066\u3044\u306a\u3044\u3053\u3068\u304b\u3089\u3001\u539a\u52b4\u7701\u306f\u7dca\u6025\u547d\u4ee4\u3092\u51fa\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3055\u3089\u306b2026\u5e744\u670821\u65e5\u306e\u539a\u52b4\u7701\u8cc7\u6599\u3067\u306f\u3001\u5225\u306e\u533b\u7642\u6a5f\u95a2\u3067\u540c\u3058\u304f\u81ea\u5bb6\u8102\u80aa\u7531\u6765\u9593\u8449\u7cfb\u5e79\u7d30\u80de\u3092\u7528\u3044\u305f\u6162\u6027\u75bc\u75db\u6cbb\u7642\u3092\u53d7\u3051\u305f\u60a3\u8005\u306e\u3046\u3061\u3001<strong>\u5c11\u306a\u304f\u3068\u30825\u540d\u304c\u60aa\u5bd2\u30fb\u767a\u71b1\u30fb\u5614\u6c17\u306a\u3069\u3092\u8a34\u3048\u3001\u5c11\u306a\u304f\u3068\u30821\u540d\u304c\u5165\u9662\u52a0\u7642\u3092\u8981\u3057\u305f<\/strong>\u3053\u3068\u304c\u78ba\u8a8d\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<style data-wp-block-html=\"css\">\n.reference-box {\n    margin: 40px 0;\n    padding: 5% 5% 0 5%;\n    background: #fffafc;\n    border: 1px solid #f4d9e2;\n    border-radius: 20px;\nline-height: 1.3;\n}\n\n.reference-title {\n    font-size: 24px;\n    color: #5b4b4b;\n}\n\n.reference-note {\n    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#a94462;\n    text-decoration: underline;\n}\n\n.reference-list span {\n    display: block;\n    color: #666;\n    font-size: 14px;\n    line-height: 1.7;\n}\n<\/style>\n\n<section class=\"reference-box\">\n  <div class=\"reference-title\">\u53c2\u8003\u6587\u732e\u30fb\u53c2\u8003\u30ea\u30f3\u30af<\/div>\n  <p class=\"reference-note\">\n    \u4e0b\u8a18\u306e\u60c5\u5831\u3092\u53c2\u8003\u306b\u8a18\u8ff0\u3057\u3066\u3044\u307e\u3059\u3002\n  <\/p>\n\n  <ul class=\"reference-list\">\n    <li>\n      <a href=\"https:\/\/www.who.int\/publications\/i\/item\/9789240115583\" target=\"_blank\" rel=\"noopener noreferrer\">\n        PubMed\uff08PMID: 38958077\uff09\n      <\/a>\n      <span>Van Delen M, Derdelinckx J, Wouters K, Nelissen I, Cools N. A systematic review and meta-analysis of clinical trials assessing safety and efficacy of human extracellular vesicle-based therapy. J Extracell Vesicles. 2024 Jul;13(7):e12458.<\/span>\n    <\/li>\n  <\/ul>\n<\/section>\n\n\n\n<h2 id=\"aioseo-\u30a8\u30af\u30bd\u30bd\u30fc\u30e0\u70b9\u9f3b\u306e\u526f\u4f5c\u7528\u3068\u78ba\u8a8d\u3057\u3066\u304a\u304d\u305f\u3044\u6ce8\u610f\u70b9-91\" class=\"wp-block-heading\">\u30a8\u30af\u30bd\u30bd\u30fc\u30e0\u70b9\u9f3b\u306e\u526f\u4f5c\u7528\u3068\u78ba\u8a8d\u3057\u3066\u304a\u304d\u305f\u3044\u6ce8\u610f\u70b9<\/h2>\n\n\n\n<h3 id=\"aioseo-\u30a8\u30af\u30bd\u30bd\u30fc\u30e0\u70b9\u9f3b\u306b\u306f\u3069\u306e\u3088\u3046\u306a\u526f\u4f5c\u7528\u304c\u3042\u308b-92\" class=\"wp-block-heading\">\u30a8\u30af\u30bd\u30bd\u30fc\u30e0\u70b9\u9f3b\u306b\u306f\u3069\u306e\u3088\u3046\u306a\u526f\u4f5c\u7528\u304c\u3042\u308b\uff1f<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">\u30a8\u30af\u30bd\u30bd\u30fc\u30e0\u70b9\u9f3b\u3067\u306f\u3001<strong>\u9f3b\u306e\u523a\u6fc0\u611f\u3084\u9055\u548c\u611f\u30fb\u9f3b\u6c34\u30fb\u304f\u3057\u3083\u307f\u30fb\u9f3b\u3065\u307e\u308a\u306a\u3069\u3001\u70b9\u9f3b\u306b\u4f34\u3046\u5c40\u6240\u7684\u306a\u75c7\u72b6<\/strong>\u304c\u751f\u3058\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\u307e\u305f\u3001\u751f\u4f53\u7531\u6765\u306e\u6210\u5206\u3092\u4f7f\u7528\u3059\u308b\u88fd\u5264\u3067\u3042\u3063\u3066\u3082\u3001\u30a2\u30ec\u30eb\u30ae\u30fc\u3084\u904e\u654f\u53cd\u5fdc\u306a\u3069\u306e\u30ea\u30b9\u30af\u3092\u5b8c\u5168\u306b\u5426\u5b9a\u3059\u308b\u3053\u3068\u306f\u3067\u304d\u307e\u305b\u3093\u3002<\/p>\n\n\n\n<p 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0;\n}\n\n.related-slim-text h3{\n  font-size: 15px;\n  margin: 0 0 4px;\n  color: #333;\nborder-bottom: none;\n    font-weight: bold;\n    padding: 0 0 5px 0\n}\n\n.related-slim-text p{\n  font-size: 12px;\n  margin: 0;\n  color: #777;\n  line-height: 1.4;\n}\n\n\/* \u30b9\u30de\u30db\u6700\u9069\u5316 *\/\n@media (max-width: 768px){\n  .related-slim-card{\n    padding: 10px;\n  }\n\n  .related-slim-card img{\n    width: 60px;\n    height: 60px;\n  }\n\n  .related-slim-text h3{\n    font-size: 14px;\n  }\n\n  .related-slim-text p{\n    font-size: 11px;\n  }\n}\n<\/style>\n\n<section class=\"related-slim\">\n  <h2>\u95a2\u9023\u8a18\u4e8b<\/h2>\n  <a href=\"https:\/\/maekawa.clinic\/column\/exosome\/exosome-nasal-spray-effects-usage-side-effects-2\/#aioseo-%E3%82%A8%E3%82%AF%E3%82%BD%E3%82%BD%E3%83%BC%E3%83%A0%E7%82%B9%E9%BC%BB%E3%81%A7%E8%80%83%E3%81%88%E3%82%89%E3%82%8C%E3%82%8B%E5%89%AF%E4%BD%9C%E7%94%A8%E3%83%AA%E3%82%B9%E3%82%AF-95\" class=\"related-slim-card\">\n    <img decoding=\"async\" src=\"https:\/\/maekawa.clinic\/column\/wp-content\/uploads\/2026\/07\/%E3%82%A8%E3%82%AD%E3%82%BD%E3%82%BD%E3%83%BC%E3%83%A0%E7%82%B9%E9%BC%BB%E3%81%A8%E3%81%AF%EF%BC%9F%E3%82%B5%E3%83%A0%E3%83%8D%E3%82%A4%E3%83%AB-1200x630.jpg\" alt=\"\u30b5\u30e0\u30cd\u30a4\u30eb\">\n    <div class=\"related-slim-text\">\n      <h3>\u30a8\u30af\u30bd\u30bd\u30fc\u30e0\u70b9\u9f3b\u3067\u8003\u3048\u3089\u308c\u308b\u526f\u4f5c\u7528\u30fb\u30ea\u30b9\u30af\u306b\u3064\u3044\u3066<\/h3>\n<p>\u30a8\u30af\u30bd\u30bd\u30fc\u30e0\u70b9\u9f3b\u3068\u306f\uff1f\u52b9\u679c\u30fb\u4f7f\u3044\u65b9\u30fb\u526f\u4f5c\u7528\u307e\u3067\u5fb9\u5e95\u89e3\u8aac<\/p>\n    <\/div>\n  <\/a>\n<\/section>\n\n\n\n<h2 id=\"aioseo-\u5b89\u5168\u306b\u6cbb\u7642\u3092\u53d7\u3051\u308b\u305f\u3081\u306b\u306f\u533b\u7642\u6a5f\u95a2\u9078\u3073\u3082\u91cd\u8981-102\" 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data-wp-block-html=\"css\">\n.related-slim{\n  margin-top: 50px;\n}\n\n.related-slim h2{\n  font-size: 20px;\n  margin-bottom: 14px;\n  border-left: 4px solid #c75c7c;\n  padding-left: 10px;\n}\n\n.related-slim-card{\n  display: flex;\n  gap: 12px;\n  align-items: center;\n  padding: 12px;\n  margin-bottom: 12px;\n  border: 1px solid #eee;\n  border-radius: 12px;\n  text-decoration: none;\n  background: #fff;\n  transition: 0.2s;\n}\n\n.related-slim-card:hover{\n  border-color: #f2b6c5;\n  transform: translateY(-2px);\n}\n\n.related-slim-card img{\n  width: 140px;\n  height: 72px;\n  object-fit: cover;\n  border-radius: 10px;\n  flex-shrink: 0;\n}\n\n.related-slim-text h3{\n  font-size: 15px;\n  margin: 0 0 4px;\n  color: #333;\nborder-bottom: none;\n    font-weight: bold;\n    padding: 0 0 5px 0\n}\n\n.related-slim-text p{\n  font-size: 12px;\n  margin: 0;\n  color: #777;\n  line-height: 1.4;\n}\n\n\/* \u30b9\u30de\u30db\u6700\u9069\u5316 *\/\n@media (max-width: 768px){\n  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