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https:\/\/maekawa.clinic\/column\/wp-content\/uploads\/2026\/08\/\u8a8d\u77e5\u75c7-\u8133\u3078\u306e\u30a2\u30d7\u30ed\u30fc\u30c1.jpg 1536w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">\u30a8\u30af\u30bd\u30bd\u30fc\u30e0\u7814\u7a76\u306e\u306a\u304b\u3067\u3082\u3001\u8133\u30fb\u795e\u7d4c\u9818\u57df\u3067\u70b9\u9f3b\u304c\u6ce8\u76ee\u3055\u308c\u308b\u7406\u7531\u306e\u4e00\u3064\u304c<strong><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-vivid-cyan-blue-color\">\u300c\u9f3b\u8154\u2212\u8133\u7d4c\u8def\uff08nose-to-brain pathway\uff09\u300d<\/mark><\/strong>\u3067\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u8133\u306b\u306f<strong>\u8840\u6db2\u8133\u95a2\u9580\uff08BBB\uff09<\/strong>\u3068\u547c\u3070\u308c\u308b\u4ed5\u7d44\u307f\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p 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class=\"wp-block-paragraph\">\u9f3b\u8154\u306b\u306f\u55c5\u795e\u7d4c\u3084\u4e09\u53c9\u795e\u7d4c\u306b\u95a2\u9023\u3059\u308b\u7d4c\u8def\u304c\u3042\u308a\u3001\u3053\u308c\u3089\u3092\u4ecb\u3057\u3066\u9f3b\u8154\u304b\u3089\u4e2d\u67a2\u795e\u7d4c\u7cfb\u3078\u7269\u8cea\u3092\u79fb\u884c\u3055\u305b\u308b\u53ef\u80fd\u6027\u304c\u7814\u7a76\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p 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0 14px 0;\n    border-left: 4px solid #c75c7c;\n    padding: 0 0 0 10px;\n    background-color: transparent;\n    color: #3b4552;\n    font-weight: bold;\n}\n\n.related-slim-card{\n  display: flex;\n  gap: 12px;\n  align-items: center;\n  padding: 12px;\n  margin-bottom: 12px;\n  border: 1px solid #eee;\n  border-radius: 12px;\n  text-decoration: none;\n  background: #fff;\n  transition: 0.2s;\n}\n\n.related-slim-card:hover{\n  border-color: #f2b6c5;\n  transform: translateY(-2px);\n}\n\n.related-slim-card img{\n  width: 140px;\n  height: 72px;\n  object-fit: cover;\n  border-radius: 10px;\n  flex-shrink: 0;\n}\n\n.related-slim-text h3{\n  font-size: 15px;\n  margin: 0 0 4px;\n  color: #333;\nborder-bottom: none;\n    font-weight: bold;\n    padding: 0 0 5px 0\n}\n\n.related-slim-text p{\n  font-size: 12px;\n  margin: 0;\n  color: #777;\n  line-height: 1.4;\n}\n\n\/* \u30b9\u30de\u30db\u6700\u9069\u5316 *\/\n@media (max-width: 768px){\n  .related-slim-card{\n    padding: 10px;\n  }\n\n  .related-slim-card img{\n    width: 60px;\n    height: 60px;\n  }\n\n  .related-slim-text h3{\n    font-size: 14px;\n  }\n\n  .related-slim-text p{\n    font-size: 11px;\n  }\n}\n<\/style>\n\n<section class=\"related-slim\">\n  <h2>\u95a2\u9023\u8a18\u4e8b<\/h2>\n  <a href=\"https:\/\/maekawa.clinic\/column\/exosome\/exosome-nasal-spray-effects-usage-side-effects-2\/\" class=\"related-slim-card\">\n    <img decoding=\"async\" src=\"https:\/\/maekawa.clinic\/column\/wp-content\/uploads\/2026\/07\/%E3%82%A8%E3%82%AD%E3%82%BD%E3%82%BD%E3%83%BC%E3%83%A0%E7%82%B9%E9%BC%BB%E3%81%A8%E3%81%AF%EF%BC%9F%E3%82%B5%E3%83%A0%E3%83%8D%E3%82%A4%E3%83%AB-1200x630.jpg\" alt=\"\u30b5\u30e0\u30cd\u30a4\u30eb\">\n    <div class=\"related-slim-text\">\n      <h3>\u30a8\u30af\u30bd\u30bd\u30fc\u30e0\u70b9\u9f3b\u3068\u306f\uff1f<\/h3>\n<p>\u52b9\u679c\u30fb\u4f7f\u3044\u65b9\u30fb\u526f\u4f5c\u7528\u307e\u3067\u5fb9\u5e95\u89e3\u8aac<\/p>\n    <\/div>\n  <\/a>\n<\/section>\n\n\n\n<h2 id=\"aioseo-\u8a8d\u77e5\u6a5f\u80fd\u3078\u306e\u52b9\u679c\u306f\u3069\u3053\u307e\u3067\u7814\u7a76\u3055\u308c\u3066\u3044\u308b-26\" class=\"wp-block-heading\">\u8a8d\u77e5\u6a5f\u80fd\u3078\u306e\u52b9\u679c\u306f\u3069\u3053\u307e\u3067\u7814\u7a76\u3055\u308c\u3066\u3044\u308b\uff1f<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u30a8\u30af\u30bd\u30bd\u30fc\u30e0\u70b9\u9f3b\u306b\u3064\u3044\u3066\u306f\u3001\u3053\u308c\u307e\u3067\u52d5\u7269\u5b9f\u9a13\u3092\u4e2d\u5fc3\u306b\u7814\u7a76\u304c\u9032\u3081\u3089\u308c\u3066\u304d\u307e\u3057\u305f\u304c\u3001\u8fd1\u5e74\u3067\u306f\u30d2\u30c8\u3092\u5bfe\u8c61\u3068\u3057\u305f\u81e8\u5e8a\u7814\u7a76\u3082\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<h3 id=\"aioseo-\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u60a3\u8005\u3092\u5bfe\u8c61\u3068\u3057\u305fphase-i-ii\u8a66\u9a13-28\" class=\"wp-block-heading\">\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u60a3\u8005\u3092\u5bfe\u8c61\u3068\u3057\u305fPhase I\/II\u8a66\u9a13<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">\u6ce8\u76ee\u3055\u308c\u308b\u7814\u7a76\u306e\u4e00\u3064\u304c\u3001\u8efd\u5ea6\u301c\u4e2d\u7b49\u5ea6\u306e\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u60a3\u8005\u3092\u5bfe\u8c61\u3068\u3057\u3066\u884c\u308f\u308c\u305fPhase I\/II\u81e8\u5e8a\u8a66\u9a13\u3067\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3053\u306e\u7814\u7a76\u3067\u306f\u3001\u8102\u80aa\u7531\u6765\u9593\u8449\u7cfb\u9593\u8cea\u7d30\u80de\u304b\u3089\u5f97\u3089\u308c\u305f\u30a8\u30af\u30bd\u30bd\u30fc\u30e0\u3092\u9f3b\u304b\u3089\u90312\u56de\u300112\u9031\u9593\u6295\u4e0e\u3057\u3001\u5b89\u5168\u6027\u3084\u8a8d\u77e5\u6a5f\u80fd\u306e\u5909\u5316\u306a\u3069\u304c\u8a55\u4fa1\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p 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\u30a8\u30af\u30bd\u30bd\u30fc\u30e0\u306e\u70b9\u9f3b\u6295\u4e0e\u304c\u4e2d\u9ad8\u9f62\u8005\u306e\u8a8d\u77e5\u6a5f\u80fd\u30fb\u514d\u75ab\u8001\u5316\u30fb\u7b4b\u529b\u306b\u53ca\u307c\u3059\u5f71\u97ff:\u4e8c\u91cd\u76f2\u691c\u7121\u4f5c\u70ba\u5316\u6bd4\u8f03\u8a66\u9a13\n      <\/a>\n      <span>jRCT\uff1a\u81e8\u5e8a\u7814\u7a76\u7b49\u63d0\u51fa\u30fb\u516c\u958b\u30b7\u30b9\u30c6\u30e0<\/span>\n    <\/li>\n  <\/ul>\n<\/section>\n\n\n\n<h2 id=\"aioseo-2026\u5e74\u306b\u3082\u8133\u306e\u8001\u5316\u795e\u7d4c\u708e\u75c7\u306b\u95a2\u3059\u308b\u7814\u7a76\u304c\u5831\u544a-41\" class=\"wp-block-heading\">2026\u5e74\u306b\u3082\u8133\u306e\u8001\u5316\u30fb\u795e\u7d4c\u708e\u75c7\u306b\u95a2\u3059\u308b\u7814\u7a76\u304c\u5831\u544a<\/h2>\n\n\n\n<p 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class=\"wp-block-paragraph\">\u3053\u306e\u7814\u7a76\u3067\u306f\u3001\u8133\u306e\u6d77\u99ac\u306b\u304a\u3044\u3066\u3001\u30a2\u30b9\u30c8\u30ed\u30b5\u30a4\u30c8\u306e\u80a5\u5927\u3084\u30df\u30af\u30ed\u30b0\u30ea\u30a2\u306e\u96c6\u7a4d\u3001\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u306a\u3069\u306e\u5909\u5316\u304c\u8a55\u4fa1\u3055\u308c\u307e\u3057\u305f\u3002\u70b9\u9f3b\u6295\u4e0e\u3057\u305f\u30de\u30a6\u30b9\u3067\u306f\u3001NLRP3\u3084cGAS-STING\u306a\u3069\u795e\u7d4c\u708e\u75c7\u306b\u95a2\u9023\u3059\u308b\u30b7\u30b0\u30ca\u30eb\u306e\u6d3b\u6027\u5316\u304c\u6291\u3048\u3089\u308c\u3001\u8a8d\u77e5\u30fb\u8a18\u61b6\u6a5f\u80fd\u306b\u3082\u6539\u5584\u304c\u307f\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p 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rel=\"noopener noreferrer\">\n        PubMed\uff08PMID: 41656949\uff09\n      <\/a>\n      <span>Madhu, Leelavathi N et al. \u201cIntranasal Human NSC-Derived EVs Therapy Can Restrain Inflammatory Microglial Transcriptome, and NLRP3 and cGAS-STING Signalling, in Aged Hippocampus.<i>\u201d Journal of extracellular vesicles<\/i> vol. 15,2 (2026): e70232. doi:10.1002\/jev2.70232<\/span>\n    <\/li>\n  <\/ul>\n<\/section>\n\n\n\n<h2 id=\"aioseo-\u30a8\u30af\u30bd\u30bd\u30fc\u30e0\u304c\u8a8d\u77e5\u6a5f\u80fd\u306b\u50cd\u304f\u53ef\u80fd\u6027\u304c\u7814\u7a76\u3055\u308c\u3066\u3044\u308b\u7406\u7531-49\" class=\"wp-block-heading\">\u30a8\u30af\u30bd\u30bd\u30fc\u30e0\u304c\u8a8d\u77e5\u6a5f\u80fd\u306b\u50cd\u304f\u53ef\u80fd\u6027\u304c\u7814\u7a76\u3055\u308c\u3066\u3044\u308b\u7406\u7531<\/h2>\n\n\n\n<p 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class=\"wp-block-paragraph\">\u4e3b\u306b\u6ce8\u76ee\u3055\u308c\u3066\u3044\u308b\u306e\u306f<\/p>\n\n\n\n<p class=\"has-text-align-center wp-block-paragraph\"><strong>\u795e\u7d4c\u708e\u75c7\u306e\u8abf\u7bc0<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u8133\u5185\u3067\u708e\u75c7\u304c\u904e\u5270\u306b\u7d9a\u304f\u3068\u3001\u795e\u7d4c\u7d30\u80de\u306e\u50cd\u304d\u306b\u5f71\u97ff\u3059\u308b\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u3002\u30a8\u30af\u30bd\u30bd\u30fc\u30e0\u306b\u306f\u3001\u3053\u3046\u3057\u305f<strong><mark style=\"background-color:rgba(0, 0, 0, 0);color:#eb718f\" class=\"has-inline-color\">\u708e\u75c7\u53cd\u5fdc\u3092\u8abf\u6574\u3059\u308b\u53ef\u80fd\u6027<\/mark><\/strong>\u304c\u7814\u7a76\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"has-text-align-center wp-block-paragraph\"><strong>\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u306e\u8efd\u6e1b<\/strong><\/p>\n\n\n\n<p 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#c75c7c;\n    font-size: 17px;\n    font-weight: 600;\n    text-decoration: none;\n    transition: 0.2s;\n}\n\n.reference-list a:hover {\n    color: #a94462;\n    text-decoration: underline;\n}\n\n.reference-list span {\n    display: block;\n    color: #666;\n    font-size: 14px;\n    line-height: 1.7;\n}\n<\/style>\n\n<section class=\"reference-box\">\n  <div class=\"reference-title\">\u53c2\u8003\u6587\u732e\u30fb\u53c2\u8003\u30ea\u30f3\u30af<\/div>\n  <p class=\"reference-note\">\n    \u4e0b\u8a18\u306e\u60c5\u5831\u3092\u53c2\u8003\u306b\u8a18\u8ff0\u3057\u3066\u3044\u307e\u3059\u3002\n  <\/p>\n\n  <ul class=\"reference-list\">\n    <li>\n      <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/30926143\/\" target=\"_blank\" rel=\"noopener noreferrer\">\n      PubMed\uff08PMID: 30926143\uff09\n      <\/a>\n      <span>Delpech, J. C., Herron, S., Botros, M. B., &amp; Ikezu, T. (2019). Neuroimmune Crosstalk through Extracellular Vesicles in Health and Disease. <i>Trends in neurosciences, 42<\/i>(5), 361\u2013372.<\/span>\n    <\/li>\n    <li>\n      <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40072028\/\" target=\"_blank\" rel=\"noopener noreferrer\">\n      PubMed\uff08PMID: 40072028\uff09\n      <\/a>\n      <span>Hermann DM, Wang C, Mohamud Yusuf A, Herz J, Doeppner TR, Giebel B. Extracellular vesicles lay the ground for neuronal plasticity by restoring mitochondrial function, cell metabolism and immune balance. <i>J Cereb Blood Flow Metab.<\/i> 2026;46(2):185-206.<\/span>\n    <\/li>\n    <li>\n      <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/39594583\/\" target=\"_blank\" rel=\"noopener noreferrer\">\n      PubMed\uff08PMID: 39594583\uff09\n      <\/a>\n      <span>Ghosh, M., &amp; Pearse, D. D. (2024). The Yin and Yang of Microglia-Derived Extracellular Vesicles in CNS Injury and Diseases. <i>Cells, 13<\/i>(22), 1834.<\/span>\n    <\/li>\n    <li>\n      <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/38338906\/\" target=\"_blank\" rel=\"noopener noreferrer\">\n      PubMed\uff08PMID: 38338906\uff09\n      <\/a>\n      <span>Filannino, F. M., Panaro, M. A., Benameur, T., Pizzolorusso, I., &#038; Porro, C. (2024). Extracellular Vesicles in the Central Nervous System: A Novel Mechanism of Neuronal Cell Communication. <i>International journal of molecular sciences, 25<\/i>(3), 1629.<\/span>\n    <\/li>\n  <\/ul>\n<\/section>\n\n\n\n<h2 id=\"aioseo-\u30a8\u30af\u30bd\u30bd\u30fc\u30e0\u70b9\u9f3b\u306f\u8a8d\u77e5\u75c7\u306e\u6cbb\u7642\u3068\u3057\u3066\u4f7f\u3048\u308b-68\" class=\"wp-block-heading\">\u30a8\u30af\u30bd\u30bd\u30fc\u30e0\u70b9\u9f3b\u306f\u8a8d\u77e5\u75c7\u306e\u6cbb\u7642\u3068\u3057\u3066\u4f7f\u3048\u308b\uff1f<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u73fe\u6642\u70b9\u3067\u306f\u3001\u30a8\u30af\u30bd\u30bd\u30fc\u30e0\u70b9\u9f3b\u3092\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u306a\u3069\u306e\u8a8d\u77e5\u75c7\u306b\u5bfe\u3059\u308b\u78ba\u7acb\u3055\u308c\u305f\u6cbb\u7642\u6cd5\u3068\u8003\u3048\u308b\u3053\u3068\u306f\u3067\u304d\u307e\u305b\u3093\u3002<\/p>\n\n\n\n<p 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class=\"wp-block-paragraph\">\u307e\u305f\u3001\u65e5\u672c\u3067\u3082\u8a8d\u77e5\u6a5f\u80fd\u3092\u5bfe\u8c61\u3068\u3057\u305f\u30a8\u30af\u30bd\u30bd\u30fc\u30e0\u70b9\u9f3b\u7814\u7a76\u304c\u767b\u9332\u3055\u308c\u307e\u3057\u305f\u304c\u3001\u7814\u7a76\u306f\u4e2d\u6b62\u3055\u308c\u3001\u5b9f\u65bd\u75c7\u4f8b\u6570\u306f0\u4eba\u3067\u3057\u305f\u3002\u305d\u306e\u305f\u3081\u3001\u3053\u306e\u7814\u7a76\u304b\u3089\u6709\u52b9\u6027\u3092\u793a\u3059\u81e8\u5e8a\u30c7\u30fc\u30bf\u306f\u5f97\u3089\u308c\u3066\u3044\u307e\u305b\u3093\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u4e00\u65b9\u3001\u52d5\u7269\u7814\u7a76\u3067\u306f\u3001\u52a0\u9f62\u3057\u305f\u30de\u30a6\u30b9\u3078\u306e\u70b9\u9f3b\u6295\u4e0e\u306b\u3088\u3063\u3066\u795e\u7d4c\u708e\u75c7\u3084\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u3001\u8a8d\u77e5\u30fb\u8a18\u61b6\u6a5f\u80fd\u306b\u95a2\u9023\u3059\u308b\u5909\u5316\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p 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alt=\"\u30b5\u30e0\u30cd\u30a4\u30eb\">\n    <div class=\"related-slim-text\">\n      <h3>2024\u5e74\uff5c\u539a\u751f\u52b4\u50cd\u7701\u3082\u30a8\u30af\u30bd\u30bd\u30fc\u30e0\u7b49\u306b\u3064\u3044\u3066\u6ce8\u610f\u559a\u8d77<\/h3>\n<p>\u30a8\u30af\u30bd\u30bd\u30fc\u30e0\u70b9\u9f3b\u306f\u5371\u967a\uff1f\u6b7b\u4ea1\u4e8b\u4f8b\u30fb\u526f\u4f5c\u7528\u30fb\u5b89\u5168\u6027\u3068\u6cbb\u7642\u524d\u306e\u6ce8\u610f\u70b9\u3092\u89e3\u8aac<\/p>\n    <\/div>\n  <\/a>\n<\/section>\n\n\n\n<h2 id=\"aioseo-\u307e\u3068\u3081-90\" class=\"wp-block-heading\">\u307e\u3068\u3081<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u30a8\u30af\u30bd\u30bd\u30fc\u30e0\u70b9\u9f3b\u306f\u3001\u9f3b\u8154\u304b\u3089\u4e2d\u67a2\u795e\u7d4c\u7cfb\u3078\u306e\u7269\u8cea\u306e\u9001\u9054\u3092\u76ee\u6307\u3059\u300cnose-to-brain delivery\u300d\u306e\u4e00\u3064\u3068\u3057\u3066\u3001\u8133\u30fb\u795e\u7d4c\u9818\u57df\u3067\u7814\u7a76\u304c\u9032\u3081\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u52d5\u7269\u7814\u7a76\u3067\u306f\u3001\u795e\u7d4c\u708e\u75c7\u3084\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u306e\u8efd\u6e1b\u3001\u795e\u7d4c\u7d30\u80de\u306e\u4fdd\u8b77\u3001\u8a8d\u77e5\u30fb\u8a18\u61b6\u6a5f\u80fd\u3078\u306e\u597d\u307e\u3057\u3044\u5909\u5316\u306a\u3069\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3055\u3089\u306b\u3001\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u60a3\u8005\u3092\u5bfe\u8c61\u3068\u3057\u305fPhase I\/II\u81e8\u5e8a\u8a66\u9a13\u3067\u306f\u3001\u70b9\u9f3b\u6295\u4e0e\u306e\u5b89\u5168\u6027\u3068\u3068\u3082\u306b\u3001\u4e00\u90e8\u306e\u8a8d\u77e5\u6a5f\u80fd\u8a55\u4fa1\u6307\u6a19\u3067\u6539\u5584\u304c\u307f\u3089\u308c\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p 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