{"id":897,"date":"2026-08-28T19:41:00","date_gmt":"2026-08-28T10:41:00","guid":{"rendered":"https:\/\/maekawa.clinic\/column\/?p=897"},"modified":"2026-09-25T18:43:52","modified_gmt":"2026-09-25T09:43:52","slug":"exosome-nasal-spray-male-menopause-testosterone","status":"publish","type":"post","link":"https:\/\/maekawa.clinic\/column\/exosome\/exosome-nasal-spray-male-menopause-testosterone\/","title":{"rendered":"\u30a8\u30af\u30bd\u30bd\u30fc\u30e0\u70b9\u9f3b\u306f\u7537\u6027\u66f4\u5e74\u671f\u306b\u52b9\u679c\u304c\u3042\u308b\uff1f\u7814\u7a76\u304b\u3089\u671f\u5f85\u3055\u308c\u308b\u53ef\u80fd\u6027\u3092\u89e3\u8aac"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\"><strong><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color 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href=\"#aioseo-\u7537\u6027\u66f4\u5e74\u671f\u306a\u3089\u30a8\u30af\u30bd\u30bd\u30fc\u30e0\u70b9\u9f3b\u3092\u53d7\u3051\u305f\u65b9\u304c\u3044\u3044\u3067\u3059\u304b-90\">\u30a8\u30af\u30bd\u30bd\u30fc\u30e0\u70b9\u9f3b\u3068\u30c6\u30b9\u30c8\u30b9\u30c6\u30ed\u30f3\u88dc\u5145\u7642\u6cd5\u306f\u540c\u3058\u3067\u3059\u304b\uff1f<\/a><\/li><li><a class=\"aioseo-toc-item\" href=\"#aioseo-\u7537\u6027\u66f4\u5e74\u671f\u306a\u3089\u30a8\u30af\u30bd\u30bd\u30fc\u30e0\u70b9\u9f3b\u3092\u53d7\u3051\u305f\u65b9\u304c\u3044\u3044\u3067\u3059\u304b-90\">\u30a8\u30af\u30bd\u30bd\u30fc\u30e0\u70b9\u9f3b\u3067\u30c6\u30b9\u30c8\u30b9\u30c6\u30ed\u30f3\u306f\u5897\u3048\u307e\u3059\u304b\uff1f<\/a><\/li><\/ul><\/li><li><a class=\"aioseo-toc-item\" href=\"#aioseo-\u307e\u3068\u3081-121\">\u307e\u3068\u3081<\/a><\/li><\/ul><\/div>\n\n\n<h2 id=\"aioseo-\u7537\u6027\u66f4\u5e74\u671floh\u75c7\u5019\u7fa4\u3068\u306f-7\" 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class=\"wp-block-paragraph\">\u7537\u6027\u66f4\u5e74\u671f\u3068\u3057\u3066\u77e5\u3089\u308c\u308bLOH\u75c7\u5019\u7fa4\u306f\u3001\u30c6\u30b9\u30c8\u30b9\u30c6\u30ed\u30f3\u306e\u4f4e\u4e0b\u306a\u3069\u3092\u80cc\u666f\u3068\u3057\u3066\u3001\u8eab\u4f53\u30fb\u7cbe\u795e\u30fb\u6027\u6a5f\u80fd\u306b\u3055\u307e\u3056\u307e\u306a\u75c7\u72b6\u304c\u73fe\u308c\u308b\u72b6\u614b\u3067\u3059\u3002<\/p>\n\n\n\n<style data-wp-block-html=\"css\">\n.alert-box {\n    margin: 32px 0;\n    padding: 24px;\n    background: #fff8f4;\n    border: 1px solid #ffd2bf;\n    border-left: 6px solid #ff7b42;\n    border-radius: 12px;\n}\n\n.alert-title {\n    font-size: 20px;\n    font-weight: 700;\n    color: #d84315;\n    margin-bottom: 14px;\n}\n\n.alert-text {\n    margin-bottom: 16px;\n    color: #444;\n    line-height: 1.9;\n}\n\n.alert-list {\n    margin: 0!important;\n    padding-left: 22px;\n}\n\n.alert-list li {\n    margin-bottom: 10px;\n    line-height: 1.8;\n}\n\n.alert-list 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font-weight: 700;<br \/>\n    color: #d84315;<br \/>\n    margin-bottom: 14px;<br \/>\n}<\/p>\n<p>.alert-text {<br \/>\n    margin-bottom: 16px;<br \/>\n    color: #444;<br \/>\n    line-height: 1.9;<br \/>\n}<\/p>\n<p>.alert-list {<br \/>\n    margin: 0!important;<br \/>\n    padding-left: 22px;<br \/>\n}<\/p>\n<p>.alert-list li {<br \/>\n    margin-bottom: 8px;<br \/>\n    line-height: 1.8;<br \/>\n}<\/p>\n<p>.alert-list li:last-child {<br \/>\n    margin-bottom: 0;<br \/>\n}<\/p>\n<p>.alert-list strong {<br \/>\n    color: #c62828;<br \/>\n}<br \/>\n<\/style>\n\n\n\n<style data-wp-block-html=\"css\">\n.reference-box {\n    margin: 40px 0;\n    padding: 5% 5% 0 5%;\n    background: #fffafc;\n    border: 1px solid #f4d9e2;\n    border-radius: 20px;\nline-height: 1.3;\n}\n\n.reference-title {\n    font-size: 24px;\n    color: #5b4b4b;\n}\n\n.reference-note {\n    color: #777;\n    font-size: 12px;\n    line-height: 1.8;\nmargin-bottom: 0!important;\n}\n\n.reference-list {\n    list-style: none!important;\n    padding: 0;\n    margin: 0!important;\n}\n\n.reference-list li {\n    padding: 20px 0;\n    border-bottom: 1px solid #f1e5ea;\n}\n\n.reference-list li:last-child {\n    border-bottom: none;\n}\n\n.reference-list a {\n    display: block;\n    margin-bottom: 6px;\n    color: #c75c7c;\n    font-size: 17px;\n    font-weight: 600;\n    text-decoration: none;\n    transition: 0.2s;\n}\n\n.reference-list a:hover {\n    color: #a94462;\n    text-decoration: underline;\n}\n\n.reference-list span {\n    display: block;\n    color: #666;\n    font-size: 14px;\n    line-height: 1.7;\n}\n<\/style>\n\n<section class=\"reference-box\">\n  <div class=\"reference-title\">\u53c2\u8003\u6587\u732e\u30fb\u53c2\u8003\u30ea\u30f3\u30af<\/div>\n  <p class=\"reference-note\">\n    \u4e0b\u8a18\u306e\u60c5\u5831\u3092\u53c2\u8003\u306b\u8a18\u8ff0\u3057\u3066\u3044\u307e\u3059\u3002\n  <\/p>\n\n  <ul class=\"reference-list\">\n    <li>\n      <a href=\"https:\/\/jsmh.jp\/loh\/\" target=\"_blank\" rel=\"noopener noreferrer\">\n        LOH\u75c7\u5019\u7fa4\u30fb\u7537\u6027\u66f4\u5e74\u671f\u3068\u306f\n      <\/a>\n      <span>\u4e00\u822c\u793e\u56e3\u6cd5\u4eba\u65e5\u672c\u30e1\u30f3\u30ba\u30d8\u30eb\u30b9\u533b\u5b66\u4f1a<\/span>\n    <\/li>\n    <li>\n      <a href=\"https:\/\/doi.org\/10.1111\/iju.15160\" target=\"_blank\" rel=\"noopener noreferrer\">\n        Summary of the clinical practice manual for late-onset hypogonadism\n      <\/a>\n      <span>Wiley Online Library<\/span>\n    <\/li>\n  <\/ul>\n<\/section>\n\n\n\n<h2 id=\"aioseo-\u7537\u6027\u66f4\u5e74\u671f\u306f\u3069\u306e\u3088\u3046\u306b\u8a3a\u65ad\u6cbb\u7642\u3059\u308b-12\" class=\"wp-block-heading\">\u7537\u6027\u66f4\u5e74\u671f\u306f\u3069\u306e\u3088\u3046\u306b\u8a3a\u65ad\u30fb\u6cbb\u7642\u3059\u308b\uff1f<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u7537\u6027\u66f4\u5e74\u671f\u306e\u8a3a\u65ad\u3067\u306f\u3001\u75c7\u72b6\u306b\u3064\u3044\u3066\u306e\u554f\u8a3a\u3068\u3068\u3082\u306b\u3001\u8840\u6db2\u691c\u67fb\u306b\u3088\u308b\u30c6\u30b9\u30c8\u30b9\u30c6\u30ed\u30f3\u306e\u8a55\u4fa1\u304c\u91cd\u8981\u3067\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u65e5\u672c\u306e2022\u5e74\u7248LOH\u8a3a\u7642\u624b\u5f15\u304d\u3067\u306f\u75c7\u72b6\u304c\u3042\u308b\u5834\u5408\u3001<strong>\u7dcf\u30c6\u30b9\u30c8\u30b9\u30c6\u30ed\u30f3250 ng\/dL\u672a\u6e80<\/strong>\u3092\u4e00\u3064\u306e\u57fa\u6e96\u3068\u3057\u3001\u7dcf\u30c6\u30b9\u30c8\u30b9\u30c6\u30ed\u30f3\u304c250 ng\/dL\u4ee5\u4e0a\u3067\u3082\u75c7\u72b6\u304c\u5f37\u3044\u5834\u5408\u306b\u306f<strong>\u904a\u96e2\u30c6\u30b9\u30c8\u30b9\u30c6\u30ed\u30f3\u3092\u6e2c\u5b9a\u3057\u30017.5 pg\/mL\u672a\u6e80<\/strong>\u3092\u57fa\u6e96\u3068\u3057\u3066\u7dcf\u5408\u7684\u306b\u5224\u65ad\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u305f\u3060\u3057\u3001\u30c6\u30b9\u30c8\u30b9\u30c6\u30ed\u30f3\u5024\u3060\u3051\u3067\u8a3a\u65ad\u3059\u308b\u306e\u3067\u306f\u306a\u304f\u3001\u75c7\u72b6\u3084\u75c5\u6b74\u3001\u8eab\u4f53\u72b6\u614b\u306a\u3069\u3092\u542b\u3081\u3066\u7dcf\u5408\u7684\u306b\u8a55\u4fa1\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u6cbb\u7642\u3067\u306f\u751f\u6d3b\u7fd2\u6163\u3078\u306e\u30a2\u30d7\u30ed\u30fc\u30c1\u3084\u75c7\u72b6\u306b\u5fdc\u3058\u305f\u6cbb\u7642\u3092\u884c\u3044\u3001\u5fc5\u8981\u3068\u5224\u65ad\u3055\u308c\u305f\u5834\u5408\u306b\u306f\u30c6\u30b9\u30c8\u30b9\u30c6\u30ed\u30f3\u88dc\u5145\u7642\u6cd5\uff08TRT\uff09\u304c\u691c\u8a0e\u3055\u308c\u307e\u3059\u3002<\/p>\n\n\n\n<p 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0!important;\n}\n\n.reference-list {\n    list-style: none!important;\n    padding: 0;\n    margin: 0!important;\n}\n\n.reference-list li {\n    padding: 20px 0;\n    border-bottom: 1px solid #f1e5ea;\n}\n\n.reference-list li:last-child {\n    border-bottom: none;\n}\n\n.reference-list a {\n    display: block;\n    margin-bottom: 6px;\n    color: #c75c7c;\n    font-size: 17px;\n    font-weight: 600;\n    text-decoration: none;\n    transition: 0.2s;\n}\n\n.reference-list a:hover {\n    color: #a94462;\n    text-decoration: underline;\n}\n\n.reference-list span {\n    display: block;\n    color: #666;\n    font-size: 14px;\n    line-height: 1.7;\n}\n<\/style>\n\n<section class=\"reference-box\">\n  <div class=\"reference-title\">\u53c2\u8003\u6587\u732e\u30fb\u53c2\u8003\u30ea\u30f3\u30af<\/div>\n  <p class=\"reference-note\">\n    \u4e0b\u8a18\u306e\u60c5\u5831\u3092\u53c2\u8003\u306b\u8a18\u8ff0\u3057\u3066\u3044\u307e\u3059\u3002\n  <\/p>\n\n  <ul class=\"reference-list\">\n    <li>\n      <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/27355400\/\" target=\"_blank\" rel=\"noopener noreferrer\">\n        PubMed\uff08PMID: 27355400\uff09\n      <\/a>\n      <span>Cunningham GR, Stephens-Shields AJ, Rosen RC, Wang C, Bhasin S, Matsumoto AM, Parsons JK, Gill TM, Molitch ME, Farrar JT, Cella D, Barrett-Connor E, Cauley JA, Cifelli D, Crandall JP, Ensrud KE, Gallagher L, Zeldow B, Lewis CE, Pahor M, Swerdloff RS, Hou X, Anton S, Basaria S, Diem SJ, Tabatabaie V, Ellenberg SS, Snyder PJ. Testosterone Treatment and Sexual Function in Older Men With Low Testosterone Levels. J Clin Endocrinol Metab. 2016 Aug<\/span>\n    <\/li>\n    <li>\n      <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/37589949\/\" target=\"_blank\" rel=\"noopener noreferrer\">\n        PubMed\uff08PMID: 37589949\uff09\n      <\/a>\n      <span>Pencina KM, Travison TG, Cunningham GR, Lincoff AM, Nissen SE, Khera M, Miller MG, Flevaris P, Li X, Wannemuehler K, Bhasin S. Effect of Testosterone Replacement Therapy on Sexual Function and Hypogonadal Symptoms in Men with Hypogonadism. J Clin Endocrinol Metab. 2024 Jan 18<\/span>\n    <\/li>\n  <\/ul>\n<\/section>\n\n\n\n<h2 id=\"aioseo-\u30a8\u30af\u30bd\u30bd\u30fc\u30e0\u70b9\u9f3b\u3068\u306f-24\" class=\"wp-block-heading\">\u30a8\u30af\u30bd\u30bd\u30fc\u30e0\u70b9\u9f3b\u3068\u306f\uff1f<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u30a8\u30af\u30bd\u30bd\u30fc\u30e0\u306f\u3001\u7d30\u80de\u304b\u3089\u653e\u51fa\u3055\u308c\u308b\u7d30\u80de\u5916\u5c0f\u80de\uff08Extracellular Vesicles\uff1aEV\uff09\u306e\u4e00\u7a2e\u3067\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u30bf\u30f3\u30d1\u30af\u8cea\u3084\u8102\u8cea\u3001\u30de\u30a4\u30af\u30edRNA\u306a\u3069\u3055\u307e\u3056\u307e\u306a\u5206\u5b50\u3092\u904b\u3073\u3001\u7d30\u80de\u540c\u58eb\u306e\u60c5\u5831\u4f1d\u9054\u306b\u95a2\u308f\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3053\u3046\u3057\u305f\u7279\u5fb4\u304b\u3089\u3001\u795e\u7d4c\u75be\u60a3\u3001\u708e\u75c7\u3001\u7d44\u7e54\u4fee\u5fa9\u306a\u3069\u5e45\u5e83\u3044\u9818\u57df\u3078\u306e\u5fdc\u7528\u304c\u7814\u7a76\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u305d\u306e\u6295\u4e0e\u7d4c\u8def\u306e\u4e00\u3064\u3068\u3057\u3066\u6ce8\u76ee\u3055\u308c\u3066\u3044\u308b\u306e\u304c\u9f3b\u8154\u6295\u4e0e\u3067\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u9f3b\u304b\u3089\u6295\u4e0e\u3059\u308b\u65b9\u6cd5\u306f\u91dd\u3092\u4f7f\u308f\u306a\u3044\u975e\u4fb5\u8972\u7684\u306a\u6295\u4e0e\u7d4c\u8def\u3067\u3042\u308a\u3001\u9f3b\u8154\u304b\u3089\u4e2d\u67a2\u795e\u7d4c\u7cfb\u3078\u7269\u8cea\u3092\u5c4a\u3051\u308b\u300cnose-to-brain pathway\u300d\u3092\u5229\u7528\u3057\u305f\u30c9\u30e9\u30c3\u30b0\u30c7\u30ea\u30d0\u30ea\u30fc\u306b\u3064\u3044\u3066\u3082\u7814\u7a76\u304c\u9032\u3093\u3067\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">2025\u5e74\u306bJournal of Controlled Release\u306b\u63b2\u8f09\u3055\u308c\u305f\u30ec\u30d3\u30e5\u30fc\u3067\u3082\u3001\u7d30\u80de\u5916\u5c0f\u80de\u306e\u9f3b\u8154\u6295\u4e0e\u306b\u3064\u3044\u3066\u3001\u795e\u7d4c\u75be\u60a3\u3084\u547c\u5438\u5668\u75be\u60a3\u3078\u306e\u5fdc\u7528\u53ef\u80fd\u6027\u3068\u3068\u3082\u306b\u3001\u8133\u3078\u306e\u9001\u9054\u7d4c\u8def\u3084\u4eca\u5f8c\u89e3\u6c7a\u3059\u3079\u304d\u8ab2\u984c\u304c\u6574\u7406\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u305f\u3060\u3057\u3001<strong><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-vivid-cyan-blue-color\">\u9f3b\u304b\u3089\u6295\u4e0e\u3057\u305f\u30a8\u30af\u30bd\u30bd\u30fc\u30e0\u304c\u3069\u306e\u7a0b\u5ea6\u5438\u53ce\u3055\u308c\u3001\u3069\u3053\u3078\u3069\u308c\u3060\u3051\u5c4a\u304f\u304b\u306f\u3001\u30a8\u30af\u30bd\u30bd\u30fc\u30e0\u306e\u7531\u6765\u3084\u7c92\u5b50\u7279\u6027\u3001\u88fd\u5264\u3001\u6295\u4e0e\u6761\u4ef6\u306a\u3069\u306b\u3088\u3063\u3066\u7570\u306a\u308a\u307e\u3059\u3002<\/mark><\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u305d\u306e\u305f\u3081\u3001\u70b9\u9f3b\u3059\u308c\u3070\u30a8\u30af\u30bd\u30bd\u30fc\u30e0\u304c\u8133\u3084\u5168\u8eab\u3078\u78ba\u5b9f\u306b\u5c4a\u304f\u3068\u78ba\u7acb\u3055\u308c\u3066\u3044\u308b\u308f\u3051\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002<\/p>\n\n\n\n<style data-wp-block-html=\"css\">\n.reference-box {\n    margin: 40px 0;\n    padding: 5% 5% 0 5%;\n    background: #fffafc;\n    border: 1px solid #f4d9e2;\n    border-radius: 20px;\nline-height: 1.3;\n}\n\n.reference-title {\n    font-size: 24px;\n    color: #5b4b4b;\n}\n\n.reference-note {\n    color: #777;\n    font-size: 12px;\n    line-height: 1.8;\nmargin-bottom: 0!important;\n}\n\n.reference-list {\n    list-style: none!important;\n    padding: 0;\n    margin: 0!important;\n}\n\n.reference-list li {\n    padding: 20px 0;\n    border-bottom: 1px solid #f1e5ea;\n}\n\n.reference-list li:last-child {\n    border-bottom: none;\n}\n\n.reference-list a {\n    display: block;\n    margin-bottom: 6px;\n    color: #c75c7c;\n    font-size: 17px;\n    font-weight: 600;\n    text-decoration: none;\n    transition: 0.2s;\n}\n\n.reference-list a:hover {\n    color: #a94462;\n    text-decoration: underline;\n}\n\n.reference-list span {\n    display: block;\n    color: #666;\n    font-size: 14px;\n    line-height: 1.7;\n}\n<\/style>\n\n<section class=\"reference-box\">\n  <div class=\"reference-title\">\u53c2\u8003\u6587\u732e\u30fb\u53c2\u8003\u30ea\u30f3\u30af<\/div>\n  <p class=\"reference-note\">\n    \u4e0b\u8a18\u306e\u60c5\u5831\u3092\u53c2\u8003\u306b\u8a18\u8ff0\u3057\u3066\u3044\u307e\u3059\u3002\n  <\/p>\n\n  <ul class=\"reference-list\">\n    <li>\n      <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/39800240\/\" target=\"_blank\" rel=\"noopener noreferrer\">\n        PubMed\uff08PMID: 39800240\uff09\n      <\/a>\n      <span>S\u00e1nchez SV, Otavalo GN, Gazeau F, Silva AKA, Morales JO. Intranasal delivery of extracellular vesicles: A promising new approach for treating neurological and respiratory disorders. J Control Release. 2025 Mar 10;379:489-523. doi: 10.1016\/j.jconrel.2025.01.018. Epub 2025 Jan 18. Erratum in: J Control Release. 2025 Jul 10<\/span>\n    <\/li>\n  <\/ul>\n<\/section>\n\n\n\n<style data-wp-block-html=\"css\">\n.related-slim{\n  margin-top: 50px;\n}\n\n.related-slim h2{\n    font-size: 20px;\n    margin: 0 0 14px 0;\n    border-left: 4px solid #c75c7c;\n    padding: 0 0 0 10px;\n    background-color: transparent;\n    color: #3b4552;\n    font-weight: bold;\n}\n\n.related-slim-card{\n  display: flex;\n  gap: 12px;\n  align-items: center;\n  padding: 12px;\n  margin-bottom: 12px;\n  border: 1px solid #eee;\n  border-radius: 12px;\n  text-decoration: none;\n  background: #fff;\n  transition: 0.2s;\n}\n\n.related-slim-card:hover{\n  border-color: #f2b6c5;\n  transform: translateY(-2px);\n}\n\n.related-slim-card img{\n  width: 140px;\n  height: 72px;\n  object-fit: cover;\n  border-radius: 10px;\n  flex-shrink: 0;\n}\n\n.related-slim-text h3{\n  font-size: 15px;\n  margin: 0 0 4px;\n  color: #333;\nborder-bottom: none;\n    font-weight: bold;\n    padding: 0 0 5px 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1.8;\nmargin-bottom: 0!important;\n}\n\n.reference-list {\n    list-style: none!important;\n    padding: 0;\n    margin: 0!important;\n}\n\n.reference-list li {\n    padding: 20px 0;\n    border-bottom: 1px solid #f1e5ea;\n}\n\n.reference-list li:last-child {\n    border-bottom: none;\n}\n\n.reference-list a {\n    display: block;\n    margin-bottom: 6px;\n    color: #c75c7c;\n    font-size: 17px;\n    font-weight: 600;\n    text-decoration: none;\n    transition: 0.2s;\n}\n\n.reference-list a:hover {\n    color: #a94462;\n    text-decoration: underline;\n}\n\n.reference-list span {\n    display: block;\n    color: #666;\n    font-size: 14px;\n    line-height: 1.7;\n}\n<\/style>\n\n<section class=\"reference-box\">\n  <div class=\"reference-title\">\u53c2\u8003\u6587\u732e\u30fb\u53c2\u8003\u30ea\u30f3\u30af<\/div>\n  <p class=\"reference-note\">\n    \u4e0b\u8a18\u306e\u60c5\u5831\u3092\u53c2\u8003\u306b\u8a18\u8ff0\u3057\u3066\u3044\u307e\u3059\u3002\n  <\/p>\n\n  <ul class=\"reference-list\">\n    <li>\n      <a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC10582850\/\" target=\"_blank\" rel=\"noopener noreferrer\">\n        PubMed\uff08PMID: 37859748\uff09\n      <\/a>\n      <span>Xie X, Song Q, Dai C, Cui S, Tang R, Li S, Chang J, Li P, Wang J, Li J, Gao C, Chen H, Chen S, Ren R, Gao X, Wang G. Clinical safety and efficacy of allogenic human adipose mesenchymal stromal cells-derived exosomes in patients with mild to moderate Alzheimer&#8217;s disease: a phase I\/II clinical trial. Gen Psychiatr. 2023 Oct 11<\/span>\n    <\/li>\n    <li>\n      <a href=\"https:\/\/clinicaltrials.gov\/study\/NCT04388982\" target=\"_blank\" rel=\"noopener noreferrer\">\n        the Safety and the Efficacy Evaluation of Allogenic Adipose MSC-Exos in Patients With Alzheimer&#8217;s Disease\n      <\/a>\n      <span>ClinicalTrials.gov<\/span>\n    <\/li>\n    <li>\n      <a href=\"https:\/\/jrct.mhlw.go.jp\/latest-detail\/jRCT1033250410\" target=\"_blank\" rel=\"noopener noreferrer\">\n        \tiPS\u7d30\u80de\u7531\u6765\u30a8\u30af\u30bd\u30bd\u30fc\u30e0\u306e\u70b9\u9f3b\u6295\u4e0e\u306b\u3088\u308b\u8efd\u5ea6\u8a8d\u77e5\u6a5f\u80fd\u969c\u5bb3\u306b\u5bfe\u3059\u308b\u5b89\u5168\u6027\u3068\u6709\u52b9\u6027\u306e\u691c\u8a0e\n      <\/a>\n      <span>jRCT \u81e8\u5e8a\u7814\u7a76\u7b49\u63d0\u51fa\u30fb\u516c\u958b\u30b7\u30b9\u30c6\u30e0<\/span>\n    <\/li>\n  <\/ul>\n<\/section>\n\n\n\n<h2 id=\"aioseo-\u30a8\u30af\u30bd\u30bd\u30fc\u30e0\u70b9\u9f3b\u306f\u7537\u6027\u66f4\u5e74\u671f\u306b\u671f\u5f85\u3067\u304d\u308b-47\" class=\"wp-block-heading\">\u30a8\u30af\u30bd\u30bd\u30fc\u30e0\u70b9\u9f3b\u306f\u7537\u6027\u66f4\u5e74\u671f\u306b\u671f\u5f85\u3067\u304d\u308b\uff1f<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u73fe\u6642\u70b9\u3067\u306f\u3001\u7537\u6027\u66f4\u5e74\u671f\uff08LOH\u75c7\u5019\u7fa4\uff09\u306e\u60a3\u8005\u306b\u30a8\u30af\u30bd\u30bd\u30fc\u30e0\u3092\u70b9\u9f3b\u3057\u3001\u6709\u52b9\u6027\u3092\u691c\u8a3c\u3057\u305f\u81e8\u5e8a\u8a66\u9a13\u306f\u78ba\u7acb\u3055\u308c\u3066\u3044\u307e\u305b\u3093\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u305d\u306e\u305f\u3081\u3001<strong><mark style=\"background-color:rgba(0, 0, 0, 0);color:#be3e3e\" 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#5b4b4b;\n}\n\n.reference-note {\n    color: #777;\n    font-size: 12px;\n    line-height: 1.8;\nmargin-bottom: 0!important;\n}\n\n.reference-list {\n    list-style: none!important;\n    padding: 0;\n    margin: 0!important;\n}\n\n.reference-list li {\n    padding: 20px 0;\n    border-bottom: 1px solid #f1e5ea;\n}\n\n.reference-list li:last-child {\n    border-bottom: none;\n}\n\n.reference-list a {\n    display: block;\n    margin-bottom: 6px;\n    color: #c75c7c;\n    font-size: 17px;\n    font-weight: 600;\n    text-decoration: none;\n    transition: 0.2s;\n}\n\n.reference-list a:hover {\n    color: #a94462;\n    text-decoration: underline;\n}\n\n.reference-list span {\n    display: block;\n    color: #666;\n    font-size: 14px;\n    line-height: 1.7;\n}\n<\/style>\n\n<section class=\"reference-box\">\n  <div class=\"reference-title\">\u53c2\u8003\u6587\u732e\u30fb\u53c2\u8003\u30ea\u30f3\u30af<\/div>\n  <p class=\"reference-note\">\n    \u4e0b\u8a18\u306e\u60c5\u5831\u3092\u53c2\u8003\u306b\u8a18\u8ff0\u3057\u3066\u3044\u307e\u3059\u3002\n  <\/p>\n\n  <ul class=\"reference-list\">\n    <li>\n      <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36537377\/\" target=\"_blank\" rel=\"noopener noreferrer\">\n        PubMed\uff08PMID: 36537377\uff09\n      <\/a>\n      <span>Liang HY, Peng F, Pan MJ, Liao SL, Wei C, Wei GY, Xie X, Xue KY, Chen MK, Yang JK, Guo WB, Liu CD, Zhou QZ. Exosomes derived from BMSCs ameliorate cyclophosphamide-induced testosterone deficiency by enhancing the autophagy of Leydig cells via the AMPK-mTOR signaling pathway. Asian J Androl. 2023<\/span>\n    <\/li>\n  <\/ul>\n<\/section>\n\n\n\n<h3 id=\"aioseo-\u6027\u6a5f\u80fd\u3078\u306e\u5fdc\u7528\u3082\u7814\u7a76\u3055\u308c\u3066\u3044\u308b-62\" class=\"wp-block-heading\">\u7537\u6027\u751f\u6b96\u6a5f\u80fd\u3068\u30a8\u30af\u30bd\u30bd\u30fc\u30e0\u306e\u7814\u7a76<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">\u7537\u6027\u66f4\u5e74\u671f\u3067\u306f\u3001\u6027\u6b32\u4f4e\u4e0b\u3084ED\uff08\u52c3\u8d77\u969c\u5bb3\uff09\u304c\u307f\u3089\u308c\u308b\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p 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class=\"wp-block-paragraph\">\u305f\u3060\u3057\u3001\u73fe\u5728\u306e\u7814\u7a76\u306e\u591a\u304f\u306f\u57fa\u790e\u7814\u7a76\u3084\u524d\u81e8\u5e8a\u7814\u7a76\u3067\u3042\u308a\u3001<strong>\u7537\u6027\u66f4\u5e74\u671f\u306b\u4f34\u3046\u6027\u6b32\u4f4e\u4e0b\u3084ED\u306b\u5bfe\u3057\u3066\u3001\u30a8\u30af\u30bd\u30bd\u30fc\u30e0\u70b9\u9f3b\u304c\u6709\u52b9\u3067\u3042\u308b\u3053\u3068\u3092\u793a\u3057\u305f\u81e8\u5e8a\u7684\u6839\u62e0\u306f\u3042\u308a\u307e\u305b\u3093\u3002<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u73fe\u6bb5\u968e\u3067\u306f\u3001\u7537\u6027\u306e\u6027\u6a5f\u80fd\u306b\u95a2\u9023\u3059\u308b\u9818\u57df\u3067\u3082\u30a8\u30af\u30bd\u30bd\u30fc\u30e0\u7814\u7a76\u304c\u9032\u3081\u3089\u308c\u3066\u3044\u308b\u72b6\u6cc1\u3067\u3059\u3002<\/p>\n\n\n\n<h3 id=\"aioseo-\u795e\u7d4c\u8a8d\u77e5\u6a5f\u80fd\u3068\u306e\u95a2\u4fc2-68\" class=\"wp-block-heading\">\u795e\u7d4c\u30fb\u8a8d\u77e5\u6a5f\u80fd\u3078\u306e\u5fdc\u7528\u7814\u7a76<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">\u75b2\u52b4\u611f\u3084\u96c6\u4e2d\u529b\u306e\u4f4e\u4e0b\u3001\u6c17\u5206\u306e\u5909\u5316\u306a\u3069\u306f\u3001\u7537\u6027\u66f4\u5e74\u671f\u306b\u4f34\u3063\u3066\u307f\u3089\u308c\u308b\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u30a8\u30af\u30bd\u30bd\u30fc\u30e0\u3092\u542b\u3080\u7d30\u80de\u5916\u5c0f\u80de\uff08EV\uff09\u306b\u3064\u3044\u3066\u306f\u3001\u795e\u7d4c\u7d30\u80de\u3092\u4fdd\u8b77\u3059\u308b\u50cd\u304d\u3084\u708e\u75c7\u53cd\u5fdc\u3068\u306e\u95a2\u4fc2\u306a\u3069\u3001\u795e\u7d4c\u7cfb\u3078\u306e\u4f5c\u7528\u306b\u3064\u3044\u3066\u7814\u7a76\u304c\u9032\u3081\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u7279\u306b\u30a8\u30af\u30bd\u30bd\u30fc\u30e0\u306e<strong>\u9f3b\u8154\u5185\u6295\u4e0e\u306f\u3001\u9f3b\u304b\u3089\u4e2d\u67a2\u795e\u7d4c\u7cfb\u3078\u306e\u7269\u8cea\u306e\u9001\u9054\u65b9\u6cd5\u306e\u4e00\u3064\u3068\u3057\u3066\u7814\u7a76\u3055\u308c\u3066\u304a\u308a\u3001\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u60a3\u8005\u3092\u5bfe\u8c61\u3068\u3057\u305f\u521d\u671f\u306e\u81e8\u5e8a\u7814\u7a76\u3082\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059<\/strong>\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u305f\u3060\u3057\u3001\u3053\u3046\u3057\u305f\u7814\u7a76\u306f\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u306a\u3069\u306e\u795e\u7d4c\u75be\u60a3\u3092\u5bfe\u8c61\u3068\u3057\u305f\u3082\u306e\u3067\u3042\u308a\u3001<strong>\u7537\u6027\u66f4\u5e74\u671f\u306b\u4f34\u3046\u96c6\u4e2d\u529b\u306e\u4f4e\u4e0b\u3084\u6c17\u5206\u306e\u5909\u5316\u306b\u5bfe\u3059\u308b\u52b9\u679c\u3092\u76f4\u63a5\u8abf\u3079\u305f\u3082\u306e\u3067\u306f\u3042\u308a\u307e\u305b\u3093<\/strong>\u3002<\/p>\n\n\n\n<p 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class=\"wp-block-paragraph\">\u30a8\u30af\u30bd\u30bd\u30fc\u30e0\u70b9\u9f3b\u3068\u8a8d\u77e5\u6a5f\u80fd\u306b\u3064\u3044\u3066\u884c\u308f\u308c\u3066\u3044\u308b\u7814\u7a76\u3084\u3001\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u3092\u5bfe\u8c61\u3068\u3057\u305f\u81e8\u5e8a\u7814\u7a76\u306b\u3064\u3044\u3066\u306f\u3001\u4ee5\u4e0b\u306e\u8a18\u4e8b\u3067\u8a73\u3057\u304f\u89e3\u8aac\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<div class=\"wp-block-group\"><div class=\"wp-block-group__inner-container is-layout-constrained wp-block-group-is-layout-constrained\">\n<style data-wp-block-html=\"css\">\n.related-slim{\n  margin-top: 50px;\n}\n\n.related-slim h2{\n    font-size: 20px;\n    margin: 0 0 14px 0;\n    border-left: 4px solid #c75c7c;\n    padding: 0 0 0 10px;\n    background-color: transparent;\n    color: #3b4552;\n    font-weight: bold;\n}\n\n.related-slim-card{\n  display: flex;\n  gap: 12px;\n  align-items: center;\n  padding: 12px;\n  margin-bottom: 12px;\n  border: 1px solid #eee;\n  border-radius: 12px;\n  text-decoration: none;\n  background: #fff;\n  transition: 0.2s;\n}\n\n.related-slim-card:hover{\n  border-color: #f2b6c5;\n  transform: translateY(-2px);\n}\n\n.related-slim-card img{\n  width: 140px;\n  height: 72px;\n  object-fit: cover;\n  border-radius: 10px;\n  flex-shrink: 0;\n}\n\n.related-slim-text h3{\n  font-size: 15px;\n  margin: 0 0 4px;\n  color: #333;\nborder-bottom: none;\n    font-weight: bold;\n    padding: 0 0 5px 0\n}\n\n.related-slim-text p{\n  font-size: 12px;\n  margin: 0;\n  color: #777;\n  line-height: 1.4;\n}\n\n\/* \u30b9\u30de\u30db\u6700\u9069\u5316 *\/\n@media (max-width: 768px){\n  .related-slim-card{\n    padding: 10px;\n  }\n\n  .related-slim-card img{\n    width: 60px;\n    height: 60px;\n  }\n\n  .related-slim-text h3{\n    font-size: 14px;\n  }\n\n  .related-slim-text p{\n    font-size: 11px;\n  }\n}\n<\/style>\n\n<section class=\"related-slim\">\n  <h2>\u95a2\u9023\u8a18\u4e8b<\/h2>\n  <a href=\"https:\/\/maekawa.clinic\/column\/exosome\/exosome-nasal-brain-cognitive-function-research\/#aioseo-%E3%82%A2%E3%83%AB%E3%83%84%E3%83%8F%E3%82%A4%E3%83%9E%E3%83%BC%E7%97%85%E6%82%A3%E8%80%85%E3%82%92%E5%AF%BE%E8%B1%A1%E3%81%A8%E3%81%97%E3%81%9Fphase-i-ii%E8%A9%A6%E9%A8%93-28\" class=\"related-slim-card\">\n    <figure><img decoding=\"async\" src=\"https:\/\/maekawa.clinic\/column\/wp-content\/uploads\/2026\/08\/%E3%82%A8%E3%82%AF%E3%82%BD%E3%82%BD%E3%83%BC%E3%83%A0%E7%82%B9%E9%BC%BB-%E8%AA%8D%E7%9F%A5%E7%97%87-1200x630.jpg\" alt=\"\u30b5\u30e0\u30cd\u30a4\u30eb\"><\/figure>\n    <div class=\"related-slim-text\">\n      <h3>\u8a8d\u77e5\u6a5f\u80fd\u3078\u306e\u52b9\u679c\u306f\u3069\u3053\u307e\u3067\u7814\u7a76\u3055\u308c\u3066\u3044\u308b\uff1f<\/h3>\n<p>\u30a8\u30af\u30bd\u30bd\u30fc\u30e0\u70b9\u9f3b\u306f\u8133\u6a5f\u80fd\u306b\u5bfe\u3057\u3066\u52b9\u679c\u7684\uff1f\u8a8d\u77e5\u6a5f\u80fd\u3067\u6ce8\u76ee\u3055\u308c\u308b\u7406\u7531\u3084\u9032\u3093\u3067\u3044\u308b\u7814\u7a76\u306b\u3064\u3044\u3066<\/p>\n    <\/div>\n  <\/a>\n<\/section>\n<\/div><\/div>\n\n\n\n<style data-wp-block-html=\"css\">\n.reference-box {\n    margin: 40px 0;\n    padding: 5% 5% 0 5%;\n    background: #fffafc;\n    border: 1px solid #f4d9e2;\n    border-radius: 20px;\nline-height: 1.3;\n}\n\n.reference-title {\n    font-size: 24px;\n    color: #5b4b4b;\n}\n\n.reference-note {\n    color: #777;\n    font-size: 12px;\n    line-height: 1.8;\nmargin-bottom: 0!important;\n}\n\n.reference-list {\n    list-style: none!important;\n    padding: 0;\n    margin: 0!important;\n}\n\n.reference-list li {\n    padding: 20px 0;\n    border-bottom: 1px solid #f1e5ea;\n}\n\n.reference-list li:last-child {\n    border-bottom: none;\n}\n\n.reference-list a {\n    display: block;\n    margin-bottom: 6px;\n    color: #c75c7c;\n    font-size: 17px;\n    font-weight: 600;\n    text-decoration: none;\n    transition: 0.2s;\n}\n\n.reference-list a:hover {\n    color: #a94462;\n    text-decoration: underline;\n}\n\n.reference-list span {\n    display: block;\n    color: #666;\n    font-size: 14px;\n    line-height: 1.7;\n}\n<\/style>\n\n<section class=\"reference-box\">\n  <div class=\"reference-title\">\u53c2\u8003\u6587\u732e\u30fb\u53c2\u8003\u30ea\u30f3\u30af<\/div>\n  <p class=\"reference-note\">\n    \u4e0b\u8a18\u306e\u60c5\u5831\u3092\u53c2\u8003\u306b\u8a18\u8ff0\u3057\u3066\u3044\u307e\u3059\u3002\n  <\/p>\n\n  <ul class=\"reference-list\">\n    <li>\n      <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/37859748\/\" target=\"_blank\" rel=\"noopener noreferrer\">\n        PubMed\uff08PMID: 37859748\uff09\n      <\/a>\n      <span>Xie X, Song Q, Dai C, Cui S, Tang R, Li S, Chang J, Li P, Wang J, Li J, Gao C, Chen H, Chen S, Ren R, Gao X, Wang G. Clinical safety and efficacy of allogenic human adipose mesenchymal stromal cells-derived exosomes in patients with mild to moderate Alzheimer&#8217;s disease: a phase I\/II clinical trial. Gen Psychiatr. 2023 Oct 11<\/span>\n    <\/li>\n    <li>\n      <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/41310241\/\" target=\"_blank\" rel=\"noopener noreferrer\">\n        PubMed\uff08PMID: 41310241\uff09\n      <\/a>\n      <span>Arjmand B, Mojavezi AR, Kamroo A, Yazdi RK, Rezaei-Tavirani M, Vahedi MS. Advances in Intranasal Delivery of Exosomes for Central Nervous System Disorders. Mol Neurobiol. 2025 Nov 27<\/span>\n    <\/li>\n  <\/ul>\n<\/section>\n\n\n\n<h3 id=\"aioseo-\u7537\u6027\u66f4\u5e74\u671f\u3078\u306e\u52b9\u679c\u306f\u307e\u3060\u672a\u78ba\u7acb-77\" class=\"wp-block-heading\">\u7537\u6027\u66f4\u5e74\u671f\u3078\u306e\u52b9\u679c\u306f\u307e\u3060\u78ba\u7acb\u3055\u308c\u3066\u3044\u306a\u3044<\/h3>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"683\" src=\"https:\/\/maekawa.clinic\/column\/wp-content\/uploads\/2026\/08\/\u7814\u7a76\u306e\u9032\u307f\u5177\u5408\u3092\u793a\u3059\u6bb5\u968e\u56f3-1024x683.jpg\" alt=\"\u30a8\u30af\u30bd\u30bd\u30fc\u30e0\u7814\u7a76\u306e\u9032\u5c55\u6bb5\u968e\u3092\u6a2a\u65b9\u5411\u306b\u793a\u3057\u305f\u30b7\u30f3\u30d7\u30eb\u306a\u30a4\u30e9\u30b9\u30c8\u3002\u57fa\u790e\u7814\u7a76\u3001\u52d5\u7269\u30fb\u524d\u81e8\u5e8a\u7814\u7a76\u3001\u30d2\u30c8\u81e8\u5e8a\u7814\u7a76\u3001\u7537\u6027\u66f4\u5e74\u671f\u3078\u306e\u81e8\u5e8a\u7814\u7a76\u306e\u9806\u306b\u4e26\u3073\u3001\u7537\u6027\u66f4\u5e74\u671f\u3078\u306e\u81e8\u5e8a\u7814\u7a76\u306f\u73fe\u6642\u70b9\u3067\u672a\u691c\u8a3c\u3067\u3042\u308b\u3053\u3068\u3092\u793a\u3057\u3066\u3044\u308b\u3002\" class=\"wp-image-1112\" srcset=\"https:\/\/maekawa.clinic\/column\/wp-content\/uploads\/2026\/08\/\u7814\u7a76\u306e\u9032\u307f\u5177\u5408\u3092\u793a\u3059\u6bb5\u968e\u56f3-1024x683.jpg 1024w, https:\/\/maekawa.clinic\/column\/wp-content\/uploads\/2026\/08\/\u7814\u7a76\u306e\u9032\u307f\u5177\u5408\u3092\u793a\u3059\u6bb5\u968e\u56f3-300x200.png 300w, 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